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PhD-student – Study of RNA translation in epithelial tissue

Your function within the department

The Faller lab is seeking a talented and enthusiastic individual to investigate how RNA translation is regulated in epithelial tissue.
Project
The project involves the study of RNA translation using in vivo intestinal models and 3-d organoid culture. Many mechanisms control the rate of mRNA translation in the intestine, and this project will probe these using sophisticated in vivo models and state-of-the-art genomics technology. Our ultimate goal is to identify mechanisms through which we can regulate RNA translation in cancer, and to find novel strategies that can be exploited therapeutically to improve patient outcomes.

Your profile

We are seeking a motivated PhD candidate with an interest in cancer biology, stem cell biology or RNA translation. You will be able to communicate scientific ideas effectively and have a demonstrable capability for independent thinking. Experience with in vivo models or approaches such as polysome profiling are desirable but not required.
You will have the opportunity to follow high-quality courses offered by the OOA oncology graduate school throughout your PhD.
The Netherlands Cancer Institute (NKI) is an independent research institute located in the lively city of Amsterdam. The Institute covers all major areas of molecular and cellular cancer biology, with special emphasis on mouse tumour models, functional screens, cancer cell biology and translational research. The Netherlands Cancer Institute and the Antoni van Leeuwenhoek Hospital form an integrated cancer centre, combining a research laboratory and a hospital under one roof in a single, independent organization. All hospital departments have an extensive research program, often in close collaboration with the research laboratory. This research is focused on improving cancer treatment through imaging and molecular diagnostics, new medicine, improved operating techniques, more effective radiotherapy, and combinations of these, epidemiology and psychosocial research.

State-of-the-art facilities The research groups at the NKI-AVL are supported by state-of-the-art equipment and facilities, most with dedicated support staff. The Institute has a large mouse facility with special units for transgenics, intervention studies, pathology and functional imaging, a genomics facility, a functional screening facility for RNAi and small-molecule libraries, excellent facilities for microscopy, flow-cytometry, protein expression and purification, and many more.

Inspiring international atmosphere Approximately 550 people work in the research laboratory and many of the clinicians are involved in research. Work discussions, lectures and seminars are in English and a large number of non-Dutch post-docs, students and staff members contribute to the stimulating and international atmosphere of the Institute.

Your career opportunities and terms of employment

 We offer a stimulating and interactive research environment, free use of all state-of-the-art facilities, Your temporary employment will be for a period of at least four years. The gross salary for per month for our PhD will be from € 2.665  to €3.282 according to the standard PhD scales. The terms of employment will be in accordance with the CAO Ziekenhuizen (Collective Labour Agreement for Hospitals).

Interested?

For further information visit our home page (https://www.nki.nl/divisions/oncogenomics/faller-william-group/)
For further information and addresses visit our websites ((https://www.nki.nl/divisions/oncogenomics/faller-william-group/) or contact William Faller w.faller@nki.nl .

Applications can be submitted via the portal (http://www.nki.nl/working-at-the-nki/) and should include your CV, a motivation letter and the contact information of your references.

The closing date for this vacancy is on the 30st of September.