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PhD Student – Chromosome Biology

Your function within the department

We are looking for a PhD student to join the Rowland laboratory. Research in our lab is driven by fundamental questions that touch upon the essence of chromosome biology and its links to the cell cycle and gene regulation. How does cohesin lock together the sister chromatids in S phase? How does cohesin structure chromosomes in interphase? And how does condensin drive chromosome compaction in mitosis? We aim to address such questions using a combination of genetics, genomics, biochemistry and imaging, using both human cells and budding yeast as our model systems.

Your profile

We offer a PhD studentship for an ambitious candidate with a passion for chromosome biology. A background in molecular biology is essential, and experience with microscopy, genetics, biochemistry and/or bioinformatics is appreciated.

Your career opportunities and terms of employment

You will join a dynamic international research team, and will collaborate with scientists with expertise in different disciplines. You will have the opportunity to follow high-quality courses offered by the OOA oncology graduate school throughout your PhD. Your temporary employment will be for a period of at least four years. The gross salary per month will be from € 2.567 to € 3.162 according to the standard PhD scales. The terms of employment will be in accordance with the CAO Ziekenhuizen (Collective Labour Agreement for Hospitals).

Interested?

For further information about the position, please contact Dr. Benjamin Rowland.

E-mail: b.rowland@nki.nl
Website: http://research.nki.nl/rowlandlab

Applications can be submitted through the link below, and should include your CV, a motivation letter, and the contact information of your references.

Selected reading

Haarhuis, J.H.I., van der Weide, R.H., Blomen, V.A., Yáñez-Cuna, J.O., Amendola, M., van Ruiten, M.S., Krijger, P.H.L., Teunissen, H., Medema, R.H., van Steensel, B., Brummelkamp, T.R., de Wit, E., and Rowland, B.D. (2017) The cohesin release factor WAPL restricts chromatin loop extension. Cell 169 (693-707)

Elbatsh, A.M.O., Haarhuis, J.H.I., Petela, N., Chapard, C., Fish, A., Celie, P.H., Stadnik, M., Ristic, D., Wyman, C., Medema, R.H., Nasmyth, K., and Rowland, B.D. (2016) Cohesin releases DNA through asymmetric ATPase-driven ring opening. Molecular Cell 61 (575-588)

Haarhuis, J.H.I., Elbatsh, A.M.O., and Rowland, B.D. (2014) Cohesin and its regulation: On the logic of X-shaped chromosomes. Developmental Cell 31 (7-18)

Acquisition for this vacancy is not appreciated.