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Mouse clinic - Imaging Unit

Bruker Biospec 7T MRI

Magnetic resonance imaging (MRI) is a powerful medical imaging modality that can provide anatomical and physiological information using strong magnetic fields and radiofrequency waves to manipulate the nuclear spin. Anatomical images can be formed through T1 and T2 weighted imaging, and contrast agents can be used to distinguish tumors from surrounding tissue. Physiological information can also be determine with techniques such as diffusion, perfusion, and angiography. Moreover, relative metabolite concentrations can be determined through spectroscopy. For these reasons, MRI is one of the most useful cancer imaging modalities. 

Albira PET/CT

Positron emission tomography (PET) is a type of nuclear imaging where functional information is ascertained via the injection of positron-emitting radiotracers. PET is often combined with computed tomography (CT), which provides a 3D anatomical correlation using x-rays. Together, PET/CT can be used to accurately and precisely locate tumors through the detection of high uptake of the injected radiotracer. The most commonly used tracer is 18F-fluorodeoxyglucose (FDG), which is taken up by highly energetic tissues, such as tumors. Other commonly used tracers include 68Ga-DOTATATE, which aids in the detection of neuroendocrine tumors by binding to somatostatin receptors, and 18F-choline, which can detect quickly proliferating cells such as tumors that take up choline for the generation of phospholipids in the cell membrane. Due to the abundance of radiotracers available, PET/CT is a primary detection method for several types of tumors and metastases.

MILabs USPECT/CT

Single positron emission tomography (SPECT) is another type of nuclear imaging which generates images via the detection of gamma-emitting radiotracers. The most commonly used SPECT isotope is 99mTc, which is often labelled with methylene diphosphonate in order to detect bone metastases. There are numerous SPECT radiotracers available which can be used for a variety of techniques, such as bone scans, myocardial perfusion, and radiotherapy. 

Bruker ICON 1T MRI

As mentioned earlier, MRI is a useful imaging modality used for anatomical and physiological imaging. Due to the difficulty of transporting animals between the 7T MRI and the nuclear imaging scanners, the ICON is available for the purpose of being used in conjunction with the PET/CT and SPECT/CT. MRI has an advantage over CT due to its high soft tissue contrast, which can be more useful for anatomical correlation. Thus, the ICON is available as a system to conveniently perform dual modality imaging, such as PET/MRI and SPECT/MRI.

PerkinElmer IVIS Spectrum

Optical imaging is a highly useful imaging modality for cancer research, which is used for bioluminescence, fluorescence, and Cerenkov luminescence imaging. Bioluminescence imaging is often performed via the incorporation of the luciferase protein into tumor cells that are subsequently injected into a laboratory mouse. By injecting D-luciferin, light is produced and tumor growth can be tracked by the intensity of the light. Fluorescence imaging can be likewise useful in tumor monitoring via the incorporation of fluorescent markers in the tumor cells or the injection of fluorescent dyes. Cerenkov luminescence imaging is a recently developed imaging modality that uses optical imaging to detect PET radiotracers, which offers a high throughput alternative to PET imaging. 

People working at the Mouse Clinic Imaging Unit

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