Netherlands Cancer Institute, Amsterdam, The Netherlands
Which factors push the risk of breast cancer to be this
high? - the population and individual perspective
Friday, February 1st, 2019, 11.00 hrs
Piet Borst Auditorium
First, in the national Hereditary Breast and Ovarian
cancer study Netherlands (HEBON) we enrolled members of high risk
families tested for BRCA1/2 mutations. With this study we actively
participate in two international initiatives, the prospective
International BRCA1/2 Carrier Cohort Study (IBCCS, coordinated at
NKI) and the Consortium of Investigators of Modifiers of BRCA1/2
(CIMBA, epidemiologic part, coordinated at NKI).
We aim to develop a risk prediction model that incorporates
Dutch baseline cancer risks and hormonal/lifestyle/genetic risk
factors, to be used in the clinical genetic practice.
HEBON/IBCCS/CIMBA are also a resources for studies on gene-gene and
treatment-gene interactions, studies on the late health effects of
prophylactic surgeries on breasts and ovaries, and studies on the
psychological impact of genetic testing and the subsequent
Secondly, we focus on thein uteroperiod as the time window of
interest by investigating a cohort of 12,000 women exposed to
Diethylstilbestrolin utero(DES daughters).