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18Oct 2019

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National seminar by Puck Knipscheer

Puck Knipscheer
Hubrecht Institute, Utrecht, The Netherlands

Alcohol-derived DNA interstrand crosslinks are repaired by two distinct mechanisms

Friday, October 18, 11.00 hrs
Piet Borst Auditorium      

Host     : Leila Akkari

Puck Knipscheer
Cellular processes that maintain the integrity of our genome are crucial to prevent genetic diseases such as cancer. The main interest of our laboratory is to decipher the molecular details of theseprocesses. Currently, we focus on understanding how toxic DNA lesions, called interstrand crosslinks (ICLs), are repaired, and how stable secondary DNA structures (G-quadruplexes) are resolved. We study these  processes in the context of active DNA replication and make use of Xenopus egg extracts that support highly regulated vertebrate DNA replication in vitro. In this experimental system, we can recapitulate both ICL repair and G-quadruplex replication in a test tube, allowing us to gain insights in their molecular mechanisms.

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