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Seminars

05Jun 2020

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National seminar by Jurgen Marteijn

Jurgen Marteijn
Department of Molecular Genetics, Oncode Institute, Erasmus MC, Rotterdam, The Netherlands

The cellular response to DNA damage-induced Transcription stress

Friday, June 5, 2020
Piet Borst Auditorium, Netherlands Cancer Institute, Amsterdam

Host: Jacqueline Jacobs
E-mail: j.jacobs@nki.nl

Jurgen Marteijn
Unperturbed transcription by RNA polymerase II is crucial for proper cell function and tissue homeostasis. However, when the DNA template of RNA polymerase is damaged, this will interfere with transcription. These transcription-blocking DNA lesions can cause genome-instability and cellular dysfunction. My lab studies how cells cope with the severe consequences of transcription-blocking DNA damage by studying the effects of DNA damage on transcription and how these DNA lesions are repaired by transcription-coupled repair.

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