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26Apr 2019

Back to Seminars overview

International seminar by Silvia Formenti

Silvia Formenti
Department of Radiation Oncology at Weill Cornell, New York, United States

DNA damage response and immune rejection of cancer

Friday, April 26, 2019, 11.00 hrs
Piet Borst Auditorium
Host: Gerben Borst

Silvia Formenti
Dr. Formenti has introduced a break-through strategy of recovering an immunological equilibrium in the setting of metastatic disease, by converting a metastasis into an in situ, individualized vaccine: in the presence of immune checkpoint blockade (anti-CTLA-4, anti-PDL-1) the irradiated tumor becomes an immunogenic hub, similar to a vaccine. Once successfully immunized against the irradiated site, the host can develop an anti-tumor immune response capable to reject the other metastases. In some patients with metastatic disease refractory to standard treatment the combination of local radiation and immune check point blockade has already resulted in durable complete remissions, sustained for years after treatment (without any other additional interventions). Her work has opened a new field of application for radiotherapy, whereby localized radiation can be used as an adjuvant to immunotherapy of solid tumors and lymphomas

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