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10May 2019

Back to Seminars overview

International seminar by Nicolas Thomä

Nicolas Thomä
Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland

CUL4 ubiquitin ligases: from DNA damage detection in chromatin to new modality in drug discovery

Host: Titia Sixma

Nicolas Thomä
The information stored in the genome of each cell is constantly protected against endogenous and exogenous attack. Enzymatic maintenance processes are in place that repair mutations and prevent duplication or deletion events. Thus, genetic and epigenetic information is faithfully passaged to the progeny. On a biomedical level, defects in these pathways are frequently associated with cancer. Genome integrity is maintained through large multi-component nano-machines. We focus on protein complexes at the interface of DNA repair, replication and chromatin. My laboratory has set out to combine structural biology, cell biology and complex biochemical in vitro reconstitutions to address the molecular workings of these chromatin-bound complex assemblies. Our focus is on machines that detect and repair mutations in the DNA, and those that make possible the accurate passage of epigenetic information to the daughter generation.

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