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Seminars

10Jan 2020

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International seminar by Neta Erez

Neta Erez
Department of Pathology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel

Stromal dynamic plasticity drives an inflammatory microenvironment in breast cancer metastasis

Friday, January 10, 2020, 11.00 hours
Piet Borst Auditorium, Netherlands Cancer Institute, Amsterdam, The Netherlands    

Host: Rodrigo Leite de Oliveira
E-mail: r.ld.oliveira@nki.nl

Neta Erez
The main goal of our laboratory is to uncover stromal pathways that contribute to tumorigenesis and metastasis. In an effort to discover novel target molecules for stromal-directed therapies, we combine state-of-the-art transgenic mouse models with gene expression profiling, intra-vital imaging and pre-clinical approaches to reveal the molecular events at the earliest stages of metastasis. Our main focus is on studying the role of inflammation and cancer-associated fibroblasts in breast cancer and lung metastasis, and to uncover the role of neuroinflammation in melanoma brain metastasis. Expanding our understanding of the early stages of metastatic growth is an essential prerequisite for the discovery of novel target molecules for the design of targeted therapeutics that may prevent, rather than try to cure, metastatic disease.

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