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28Jun 2019

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International seminar by James Haber

James Haber
Brandeis University, Waltham, United States

Genome Stability and Instability during Repair of a Broken Chromosome

Friday, June 28, 2019, 11.00 hrs
Piet Borst Auditorium  

Hosts     : Anna Gonzalez Manjon & Ruben Schep

Jim Haber
We are engaged in studying how breaks in the DNA double helix are repaired and in certain cellular processes that they initiate. Such DNA double strand breaks, or DSBs, can lead to chromosome instability and can be lethal if not repaired. DSBs may result from irradiation or mutagenic chemicals. They may also arise during DNA replication as a product of stalled replication forks and they can also arise in specialized processes such as mating type switching in yeast or during the process of creating immunoglobulins. Interest in DSBs also stems from the fact that DSBs sometimes result in aberrations such as chromosomal rearrangements which in some organisms can lead to the formation of cancers.

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