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Seminars

20Sep 2019

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International seminar by Gerd Blobel

Gerd Blobel 
Perelman School of Medicine, University of Pennsylvania, Philadelphia,USA

Title to be announced

Friday, September 20, 2019, 11.00 hrs
Piet Borst Auditorium

Host: Elzo de Wit

Gerd Blobel
Our lab focuses on the genetic and epigenetic control of hematopoiesis and its disorders. Specifically, we    study how tissue-specific transcription factors govern the specification and maintenance of hematopoietic cell lineages. We examine how transcription programs are epigenetically transmitted through mitosis to maintain lineage identity. Our work is leading us deeply into the analysis of chromatin structure, its modifications and organization. For example, we investigate how regulatory elements are spatially organized in the nucleus. We are developing approaches to manipulate higher order chromatin organization as a therapeutic tool for the treatment of diseases affecting the globin genes. For our studies we combine molecular, genomic, biochemical, and imaging approaches with studies in normal and gene targeted mice.

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