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06Sep 2019

Back to Seminars overview

International seminar by Gerard Evan

Gerard Evan
Department of Biochemistry, University of Cambridge, Cambridge, United Kingdom

Where cancer phenotypes come from and how to make them go away
Friday, September 6, 2019, 11.00 hrs
Piet Borst Auditorium
Hosts: Karin de Visser & Jos Jonkers

Gerard Evan
Our laboratory is developing a suite of "switchable genetic" technologies that allow the reversible systemic or tissue-specific toggling on and off of any target gene in adult mice. In this way we will overcome the great shortcoming of classical, germ-line (knock-out and transgenic) genetics, which is severely limited in its ability to define gene function in vertebrates due to embryonic lethality, developmental compensation and adaptive functional degeneracy, all of which obscure the roles played by genes in adult tissues that would normally have developed in the presence of that gene. We also employ the range of cell and molecular biology technologies to address the roles played by key oncogenic signaling pathways (E2F/Rb, Ras, Myc, HIF1a) in the genesis and progression of cancers.


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