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08Mar 2019

Back to Seminars overview

International seminar by Davide Ruggero

Davide Ruggero
University of California San Francisco, San Francisco, United States

Translating the cancer genome one codon at a time and its therapeutic implications

Friday, March 8, 2019, 11.00 hrs
Piet Borst Auditorium

Host: William Faller

Davide Ruggero
Our research is centered on understanding the molecular mechanisms by which impairments in accurate control of mRNA translation, cell growth, and overall cellular protein synthesis rates lead to cancer. While it is commonly accepted that oncogenic signaling deregulates the transcriptional profile of neoplastic cells, our research has demonstrated a pivotal role for impairments in the translational efficiency of specific existing mRNA species at the post-transcription level towards cancer initiation

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