Publications

Nature

Identification of an alternative triglyceride biosynthesis pathway.

01-09-2023

Nature

cGAS-STING drives ageing-related inflammation and neurodegeneration.

01-08-2023

Science translational medicine

Senolytic treatment preserves biliary regenerative capacity lost through cellular senescence during cold storage.

07-12-2022

Nature communications

A doxycycline- and light-inducible Cre recombinase mouse model for optogenetic genome editing.

28-10-2022

Science (New York, N.Y.)

Actin maturation requires the ACTMAP/C19orf54 protease.

30-09-2022

Laboratory investigation; a journal of technical methods and pathology

A murine mesenchymal stem cell model for initiating events in osteosarcomagenesis points to CDK4/CDK6 inhibition as a therapeutic target.

01-04-2022

Science translational medicine

Cellular senescence inhibits renal regeneration after injury in mice, with senolytic treatment promoting repair.

19-05-2021

The Journal of experimental medicine

Combined deletion of Bap1, Nf2, and Cdkn2ab causes rapid onset of malignant mesothelioma in mice.

01-06-2020

Nature communications

A natural WNT signaling variant potently synergizes with Cdkn2ab loss in skin carcinogenesis.

29-03-2019

Nature medicine

SHP2 is required for growth of KRAS-mutant non-small-cell lung cancer in vivo.

01-07-2018

Biological psychiatry

DCC Receptors Drive Prefrontal Cortex Maturation by Determining Dopamine Axon Targeting in Adolescence.

15-01-2018

Cell

Rejuvenation by Therapeutic Elimination of Senescent Cells.

23-03-2017

Cell

Wnt Down, Tumors Wind Up?

18-06-2015

Transgenic research

Improved pregnancy and birth rates with routine application of nonsurgical embryo transfer.

01-08-2014

The Journal of neuroscience : the official journal of the Society for Neuroscience

Progressive disorganization of paranodal junctions and compact myelin due to loss of DCC expression by oligodendrocytes.

16-07-2014

EMBO molecular medicine

Rapid target gene validation in complex cancer mouse models using re-derived embryonic stem cells.

01-02-2014

Translational psychiatry

dcc orchestrates the development of the prefrontal cortex during adolescence and is altered in psychiatric patients.

17-12-2013

Nature

Deleted in colorectal carcinoma suppresses metastasis in p53-deficient mammary tumours.

22-02-2012

BioEssays : news and reviews in molecular, cellular and developmental biology

Rapid validation of cancer genes in chimeras derived from established genetically engineered mouse models.

01-09-2011

Disease models & mechanisms

Mammary-specific inactivation of E-cadherin and p53 impairs functional gland development and leads to pleomorphic invasive lobular carcinoma in mice.

01-05-2011

Cancer research

Insertional mutagenesis in mice deficient for p15Ink4b, p16Ink4a, p21Cip1, and p27Kip1 reveals cancer gene interactions and correlations with tumor phenotypes.

15-01-2010

Cancer cell

A conditional mouse model for malignant mesothelioma.

01-03-2008

Nature

p15Ink4b is a critical tumour suppressor in the absence of p16Ink4a.

23-08-2007

Cancer cell

Somatic inactivation of E-cadherin and p53 in mice leads to metastatic lobular mammary carcinoma through induction of anoikis resistance and angiogenesis.

01-11-2006

The Journal of experimental medicine

The loss of PTEN allows TCR alphabeta lineage thymocytes to bypass IL-7 and Pre-TCR-mediated signaling.

04-10-2004

Cancer research

The generation of a conditional reporter that enables bioluminescence imaging of Cre/loxP-dependent tumorigenesis in mice.

01-11-2003

The Journal of experimental medicine

Contributions of the T cell receptor-associated CD3gamma-ITAM to thymocyte selection.

01-07-2002

Nature

Loss of p16Ink4a confers susceptibility to metastatic melanoma in mice.

06-09-2001

Journal of immunology (Baltimore, Md. : 1950)

A redundant role of the CD3 gamma-immunoreceptor tyrosine-based activation motif in mature T cell function.

15-02-2001

Immunity

Pre-TCR signaling and inactivation of p53 induces crucial cell survival pathways in pre-T cells.

01-07-1999

Cancer research

Identification and characterization of collaborating oncogenes in compound mutant mice.

01-04-1999

The EMBO journal

The CD3gamma chain is essential for development of both the TCRalphabeta and TCRgammadelta lineages.

01-04-1998

Nature medicine

Increased sensitivity to anticancer drugs and decreased inflammatory response in mice lacking the multidrug resistance-associated protein.

01-11-1997

Nature genetics

Epithelial detachment due to absence of hemidesmosomes in integrin beta 4 null mice.

01-07-1996

Nature

T cell depletion in transgenic mice carrying a mutant gene for TCR-beta.

26-10-1989

Cell

Predisposition to lymphomagenesis in pim-1 transgenic mice: cooperation with c-myc and N-myc in murine leukemia virus-induced tumors.

24-02-1989

The EMBO journal

Tissue-specific expression of a vimentin--desmin hybrid gene in transgenic mice.

01-04-1988

The EMBO journal

Transcription of T cell receptor beta-chain genes is controlled by a downstream regulatory element.

01-03-1988