Publications

Cancer chemotherapy and pharmacology

Pharmacokinetics and pharmacodynamics of topotecan given on a daily-times-five schedule in phase II clinical trials using a limited-sampling procedure.

Investigational new drugs

Purity determinations in the bulk drug of the novel indoloquinone antitumor agent EO9.

Anti-cancer drugs

Tissue distribution, metabolism and excretion of paclitaxel in mice.

Cancer chemotherapy and pharmacology

Evaluation of formulas using the serum creatinine level to calculate the optimal dosage of carboplatin.

Archives of medical research

Antigenic variation in trypanosomes.

Journal of chromatography. B, Biomedical applications

Quantification of paclitaxel metabolites in human plasma by high-performance liquid chromatography.

15-12-1995

Oncogene

Oncogenic activity of Tiam1 and Rac1 in NIH3T3 cells.

07-12-1995

Clinical otolaryngology and allied sciences

Heat and moisture exchangers as a treatment option in the post-operative rehabilitation of laryngectomized patients.

01-12-1995

Gastroenterology

Regulation of protein secretion into bile: studies in mice with a disrupted mdr2 p-glycoprotein gene.

01-12-1995

Journal of pharmaceutical and biomedical analysis

High-performance liquid chromatographic analysis of the new antitumour drug N-benzoylstaurosporine (CGP 41 251) and four potential metabolites in micro-volumes of plasma.

01-12-1995

PDA journal of pharmaceutical science and technology

The influence of formulation excipients on the stability of the novel antitumor agent carzelesin (U-80,244).

01-11-1995

Biochemical Society transactions

Involvement of the cell surface-bound mucin, episialin/MUC1, in progression of human carcinomas.

01-11-1995

Journal of the National Cancer Institute

Roles of radiotherapy and smoking in lung cancer following Hodgkin's disease.

18-10-1995

European journal of cancer (Oxford, England : 1990)

Cancer incidence in The Netherlands in 1989 and 1990: first results of the nationwide Netherlands cancer registry. Coordinating Committee for Regional Cancer Registries.

European journal of cancer (Oxford, England : 1990)

Risk factors for the development of oesophageal cancer as a second primary tumour.

The Journal of clinical investigation

Absence of the mdr1a P-Glycoprotein in mice affects tissue distribution and pharmacokinetics of dexamethasone, digoxin, and cyclosporin A.

Therapeutic drug monitoring

Monitoring carboplatin concentrations in saliva: a replacement for plasma ultrafiltrate measurements?

Proceedings of the National Academy of Sciences of the United States of America

Role of glutathione in the export of compounds from cells by the multidrug-resistance-associated protein.

15-08-1995

FEBS letters

A novel beta 1 integrin isoform produced by alternative splicing: unique expression in cardiac and skeletal muscle.

07-08-1995

Current biology : CB

Transcriptional regulation. Flipping the Myc switch.

01-08-1995

Cell

Inactivation of the mouse Msh2 gene results in mismatch repair deficiency, methylation tolerance, hyperrecombination, and predisposition to cancer.

28-07-1995

Cancer research

A gene for susceptibility to small intestinal cancer, ssic1, maps to the distal part of mouse chromosome 4.

15-07-1995

Cell

Antigenic variation in malaria.

14-07-1995

The EMBO journal

BS69, a novel adenovirus E1A-associated protein that inhibits E1A transactivation.

03-07-1995

British journal of cancer

CRC/EORTC/NCI Joint Formulation Working Party: experiences in the formulation of investigational cytotoxic drugs.

01-07-1995

Journal of clinical oncology : official journal of the American Society of Clinical Oncology

Phase I clinical and pharmacokinetic study of topotecan administered by a 24-hour continuous infusion.

01-07-1995

European journal of cancer (Oxford, England : 1990)

Multidrug resistance and the role of P-glycoprotein knockout mice.

01-07-1995

Journal of chromatography. B, Biomedical applications

High-performance liquid chromatographic determination of the novel antitumour drug topotecan and topotecan as the total of the lactone plus carboxylate forms, in human plasma.

09-06-1995

Genes & development

Regulation of the retinoblastoma protein-related p107 by G1 cyclin complexes.

01-06-1995

The EMBO journal

Proviral tagging in E mu-myc transgenic mice lacking the Pim-1 proto-oncogene leads to compensatory activation of Pim-2.

01-06-1995

Molecular and cellular biology

E2F-5, a new E2F family member that interacts with p130 in vivo.

01-06-1995

Cell adhesion and communication

An alternatively spliced exon in the extracellular domain of the human alpha 6 integrin subunit--functional analysis of the alpha 6 integrin variants.

International journal of radiation biology

Amelioration of radiation nephropathy by acetylsalicylic acid.

The EMBO journal

A P-glycoprotein protects Caenorhabditis elegans against natural toxins.

Journal of clinical epidemiology

Dissent: The risk of lung cancer in nonsmokers in the United States: a causal association with environmental tobacco smoke.

Nature

Transformation of axial skeleton due to overexpression of bmi-1 in transgenic mice.

20-04-1995

The Biochemical journal

Lysophosphatidic acid-induced Ca2+ mobilization in human A431 cells: structure-activity analysis.

15-04-1995

Diseases of the colon and rectum

Quality of life in colorectal cancer. Stoma vs. nonstoma patients.

International immunology

Novel mAbs reveal potent co-stimulatory activity of murine CD27.

The Journal of cell biology

Episialin (MUC1) overexpression inhibits integrin-mediated cell adhesion to extracellular matrix components.

Breast cancer research and treatment

Should tamoxifen be a primary treatment choice for elderly breast cancer patients with locoregional disease?

Cancer letters

Is episialin/MUC1 involved in breast cancer progression?

23-03-1995

Biochimica et biophysica acta

Characterization of the promoter region of the human MDR3 P-glycoprotein gene.

14-03-1995

International immunology

Assembly and intracellular transport of the human B cell antigen receptor complex.

01-03-1995

Cancer treatment reviews

High-dose chemotherapy regimens for solid tumors.

01-03-1995

Journal of cancer research and clinical oncology

The use of the Calvert formula to determine the optimal carboplatin dosage.

Experimental cell research

The cytoplasmic domain of alpha 6A integrin subunit is an in vitro substrate for protein kinase C.

Immunogenetics

A susceptibility gene for alveolar lung tumors in the mouse maps between Hsp70.3 and G7 within the H2 complex.

Cancer chemotherapy and pharmacology

Isolation, purification, and biological activity of mono- and dihydroxylated paclitaxel metabolites from human feces.