Publications

Pharmacological research

Clinical research on antiangiogenic therapy.

Methods in molecular medicine

Saturating mutagenesis and characterization of a herpesvirus genome using in vivo reconstitution of virus from cloned subgenomic regions.

Cellular and molecular life sciences : CMLS

Functional analysis of mouse Polycomb group genes.

International journal of clinical pharmacology and therapeutics

Pharmacological insights from P-glycoprotein knockout mice.

Biochimica et biophysica acta

E2F: a nodal point in cell cycle regulation.

09-12-1997

The Biochemical journal

The two phenylalanines in the GFFKR motif of the integrin alpha6A subunit are essential for heterodimerization.

Developmental dynamics : an official publication of the American Association of Anatomists

Spatial and temporal expression of the beta1D integrin during mouse development.

Molecular and biochemical parasitology

beta-D-glucosyl-hydroxymethyluracil, a novel base in African trypanosomes and other Kinetoplastida.

Genes & development

Localization of the modified base J in telomeric VSG gene expression sites of Trypanosoma brucei.

The Journal of clinical investigation

Full blockade of intestinal P-glycoprotein and extensive inhibition of blood-brain barrier P-glycoprotein by oral treatment of mice with PSC833.

15-11-1997

Patient education and counseling

Genetic counseling for hereditary cancer: a pilot study on experiences of patients and family members.

14-11-1997

Journal of molecular biology

MPc2, a new murine homolog of the Drosophila polycomb protein is a member of the mouse polycomb transcriptional repressor complex.

14-11-1997

The Journal of biological chemistry

Targeting of Tiam1 to the plasma membrane requires the cooperative function of the N-terminal pleckstrin homology domain and an adjacent protein interaction domain.

07-11-1997

The Journal of cell biology

The guanine nucleotide exchange factor Tiam1 affects neuronal morphology; opposing roles for the small GTPases Rac and Rho.

03-11-1997

Acta oto-laryngologica

Development and clinical evaluation of a second-generation voice prosthesis (Provox 2), designed for anterograde and retrograde insertion.

01-11-1997

Nature medicine

Increased sensitivity to anticancer drugs and decreased inflammatory response in mice lacking the multidrug resistance-associated protein.

01-11-1997

The Journal of experimental medicine

Peripheral T cell survival requires continual ligation of the T cell receptor to major histocompatibility complex-encoded molecules.

20-10-1997

The EMBO journal

Crystal structure of the specific DNA-binding domain of Tc3 transposase of C.elegans in complex with transposon DNA.

01-10-1997

The Journal of biological chemistry

CD95/Fas-induced ceramide formation proceeds with slow kinetics and is not blocked by caspase-3/CPP32 inhibition.

26-09-1997

Oncogene

Pim-2 transgene induces lymphoid tumors, exhibiting potent synergy with c-myc.

04-09-1997

Oncogene

Repression of c-Myc responsive genes in cycling cells causes G1 arrest through reduction of cyclin E/CDK2 kinase activity.

01-09-1997

The Journal of biological chemistry

Crystal structure of murine/human Ubc9 provides insight into the variability of the ubiquitin-conjugating system.

22-08-1997

Oncogene

Pertubation of B and T cell development and predisposition to lymphomagenesis in Emu Bmi1 transgenic mice require the Bmi1 RING finger.

18-08-1997

Journal of chromatography. B, Biomedical sciences and applications

Bio-analysis of docetaxel and hydroxylated metabolites in human plasma by high-performance liquid chromatography and automated solid-phase extraction.

15-08-1997

Journal of pharmaceutical sciences

The functional role of P-glycoprotein in the blood-brain barrier.

Seminars in oncology

Hepatic metabolism of paclitaxel and its impact in patients with altered hepatic function.

Blood

Human monocytes and neutrophils store transforming growth factor-alpha in a subpopulation of cytoplasmic granules.

Stroke

Assessing quality of life after stroke. The value and limitations of proxy ratings.

Journal of cell science

A minimal region on the integrin beta4 subunit that is critical to its localization in hemidesmosomes regulates the distribution of HD1/plectin in COS-7 cells.