Publications

Cancer chemotherapy and pharmacology

A clinical pharmacokinetics study of carzelesin given by short-term intravenous infusion in a phase I study.

02-04-1998

Annals of oncology : official journal of the European Society for Medical Oncology

Malignant effusions contain lysophosphatidic acid (LPA)-like activity.

01-04-1998

The EMBO journal

The CD3gamma chain is essential for development of both the TCRalphabeta and TCRgammadelta lineages.

01-04-1998

The Journal of clinical investigation

Drug export activity of the human canalicular multispecific organic anion transporter in polarized kidney MDCK cells expressing cMOAT (MRP2) cDNA.

01-04-1998

The Journal of biological chemistry

CD95 (Fas/APO-1) induces ceramide formation and apoptosis in the absence of a functional acid sphingomyelinase.

27-03-1998

Current biology : CB

Exogenous phospholipase D generates lysophosphatidic acid and activates Ras, Rho and Ca2+ signaling pathways.

26-03-1998

The Journal of cell biology

Acute loss of cell-cell communication caused by G protein-coupled receptors: a critical role for c-Src.

09-03-1998

Proceedings of the National Academy of Sciences of the United States of America

beta-D-glucosyl-hydroxymethyluracil is a conserved DNA modification in kinetoplastid protozoans and is abundant in their telomeres.

03-03-1998

Cell adhesion and communication

Glomerular extracellular matrix components and integrins.

01-03-1998

Molecular and biochemical parasitology

Control of VSG gene expression sites in Trypanosoma brucei.

01-03-1998

Cancer treatment reviews

Cisplatin resistance and DNA repair.

18-02-1998

Journal of the National Cancer Institute

Impairment of cognitive function in women receiving adjuvant treatment for high-risk breast cancer: high-dose versus standard-dose chemotherapy.

04-02-1998

Nederlands tijdschrift voor geneeskunde

[Last word on hormone replacement and breast cancer?].

17-01-1998

European journal of cancer (Oxford, England : 1990)

Intraperitoneal cisplatin with regional hyperthermia in advanced ovarian cancer: pharmacokinetics and cisplatin-DNA adduct formation in patients and ovarian cancer cell lines.

01-01-1998

Pharmacological research

Clinical research on antiangiogenic therapy.

01-01-1998

Methods in molecular medicine

Saturating mutagenesis and characterization of a herpesvirus genome using in vivo reconstitution of virus from cloned subgenomic regions.

01-01-1998

Cellular and molecular life sciences : CMLS

Functional analysis of mouse Polycomb group genes.

01-01-1998

International journal of clinical pharmacology and therapeutics

Pharmacological insights from P-glycoprotein knockout mice.

01-01-1998

Biochimica et biophysica acta

E2F: a nodal point in cell cycle regulation.

09-12-1997

The Biochemical journal

The two phenylalanines in the GFFKR motif of the integrin alpha6A subunit are essential for heterodimerization.

01-12-1997

Developmental dynamics : an official publication of the American Association of Anatomists

Spatial and temporal expression of the beta1D integrin during mouse development.

01-12-1997

Molecular and biochemical parasitology

beta-D-glucosyl-hydroxymethyluracil, a novel base in African trypanosomes and other Kinetoplastida.

01-12-1997

Genes & development

Localization of the modified base J in telomeric VSG gene expression sites of Trypanosoma brucei.

01-12-1997

The Journal of clinical investigation

Full blockade of intestinal P-glycoprotein and extensive inhibition of blood-brain barrier P-glycoprotein by oral treatment of mice with PSC833.

15-11-1997

Patient education and counseling

Genetic counseling for hereditary cancer: a pilot study on experiences of patients and family members.

14-11-1997

Journal of molecular biology

MPc2, a new murine homolog of the Drosophila polycomb protein is a member of the mouse polycomb transcriptional repressor complex.

14-11-1997

The Journal of biological chemistry

Targeting of Tiam1 to the plasma membrane requires the cooperative function of the N-terminal pleckstrin homology domain and an adjacent protein interaction domain.

07-11-1997

The Journal of cell biology

The guanine nucleotide exchange factor Tiam1 affects neuronal morphology; opposing roles for the small GTPases Rac and Rho.

03-11-1997

Acta oto-laryngologica

Development and clinical evaluation of a second-generation voice prosthesis (Provox 2), designed for anterograde and retrograde insertion.

01-11-1997

Nature medicine

Increased sensitivity to anticancer drugs and decreased inflammatory response in mice lacking the multidrug resistance-associated protein.

01-11-1997

The Journal of experimental medicine

Peripheral T cell survival requires continual ligation of the T cell receptor to major histocompatibility complex-encoded molecules.

20-10-1997

The EMBO journal

Crystal structure of the specific DNA-binding domain of Tc3 transposase of C.elegans in complex with transposon DNA.

01-10-1997

The Journal of biological chemistry

CD95/Fas-induced ceramide formation proceeds with slow kinetics and is not blocked by caspase-3/CPP32 inhibition.

26-09-1997

Oncogene

Pim-2 transgene induces lymphoid tumors, exhibiting potent synergy with c-myc.

04-09-1997

Oncogene

Repression of c-Myc responsive genes in cycling cells causes G1 arrest through reduction of cyclin E/CDK2 kinase activity.

01-09-1997

The Journal of biological chemistry

Crystal structure of murine/human Ubc9 provides insight into the variability of the ubiquitin-conjugating system.

22-08-1997

Oncogene

Pertubation of B and T cell development and predisposition to lymphomagenesis in Emu Bmi1 transgenic mice require the Bmi1 RING finger.

18-08-1997

Journal of chromatography. B, Biomedical sciences and applications

Bio-analysis of docetaxel and hydroxylated metabolites in human plasma by high-performance liquid chromatography and automated solid-phase extraction.

15-08-1997

Journal of pharmaceutical sciences

The functional role of P-glycoprotein in the blood-brain barrier.

01-08-1997

Seminars in oncology

Hepatic metabolism of paclitaxel and its impact in patients with altered hepatic function.

01-08-1997

Blood

Human monocytes and neutrophils store transforming growth factor-alpha in a subpopulation of cytoplasmic granules.

01-08-1997

Stroke

Assessing quality of life after stroke. The value and limitations of proxy ratings.

01-08-1997

Journal of cell science

A minimal region on the integrin beta4 subunit that is critical to its localization in hemidesmosomes regulates the distribution of HD1/plectin in COS-7 cells.

01-08-1997

Annals of oncology : official journal of the European Society for Medical Oncology

Successful intraperitoneal suramin treatment of peritoneal mesothelioma.

01-08-1997

Acta crystallographica. Section D, Biological crystallography

wARP: improvement and extension of crystallographic phases by weighted averaging of multiple-refined dummy atomic models.

01-07-1997

Biochemical and biophysical research communications

The unique cytoplasmic domain of the human integrin variant beta4E is produced by partial retention of intronic sequences.

27-06-1997

FEBS letters

Communication between the extracellular environment, cytoplasmic signalling cascades and the nuclear cell-cycle machinery.

23-06-1997

Trends in genetics : TIG

Genetic dissection of the function of mammalian P-glycoproteins.

01-06-1997

Seminars in cancer biology

The physiological function of drug-transporting P-glycoproteins.

01-06-1997

Oncogene

Bcl-2 reduces lymphomagenesis in deltaV-TCRbeta transgenic mice.

29-05-1997