I obtained my doctoral thesis studies in the laboratory of "DNA replicative stress in cancer "under the supervision of Prof. Dr. med. Matthias Dobbelstein, at Institute of Molecular Oncology of University of Göttingen (Göttingen, Germany). My Ph.D. thesis mainly focused on the understanding of how centrosome integrity can affect DNA replication independently from mitosis and chromosomal missegregation. My thesis reveals a novel connection between centrosomes integrity and DNA replication apart from mitotic insults and that through the formation of secondary structures called R-loops upon the activation of the MLK3-P38-MK2.
