Margarida L. F. Martins

I am currently studying different types of compounds, ranging from potent analgesics to potential anti-addiction agents and anti-cancer drugs. I am specifically interested in getting a better understanding of how membrane drug transporters and drug-metabolizing enzymes can have an impact on the tissue distribution and plasma exposure of those compounds. For that, we are making use of wild-type and genetically modified mouse models and cell lines, which have proved to be excellent tools to elucidate factors that affect both the safety and efficacy profiles of drugs.