Fernando Salgado Polo

Fernando Salgado Polo

PhD student

+31 20 512 2216 f.salgado@nki.nl Anastassis (Tassos) Perrakis

In July 2017, I joined the Perrakis group as a PhD student. My work focuses on two projects:

- Characterizing the catalysis and allosteric modulation of the lysophospholipase Autotaxin (ATX), the main producer of the bioactive lipid lysophosphatidic  acid (LPA), as well as the mechanism by which ATX presents its product to the LPA receptors at the cell surface.

- Understanding the intracellular trafficking and ligand specificity of several members in the glycerophosphodiester phosphodiesterase (GDE) family, namely, GDE2 and GDE3, which recognize GPI-anchored proteins.

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