Arne Nedergaard Kousholt

My primary experience lies within basic and translational cancer research; studying the role of the DNA Damage Response (DDR) for cancer prevention, and in novel personalized cancer treatments. I work as a postdoc in the lab of Jos Jonkers, where I am using mouse models to investigate the tumour suppressor role of the DDR gene, BRIP1/FANCJ. Tumours from these models will further be used for studying treatment response of clinically relevant drugs including novel targeted treatments. Moreover, I work on a CRISPR based functional assay for testing gene variants for HBOC genes. Such classifications can support risk prediction for affected families, and guide treatment decisions for cancer patients.