Alejandra Martínez Chávez
PhD student+31 20 512 2049 email@example.com Alfred Schinkel Bioanalytical Laboratory of the Pharmacy
In September 2016, I joined the groups of Alfred Schinkel and Jos Beijnen as a PhD student. My research focuses on studying the effect of detoxifying systems, especially drug transporters and drug-metabolizing enzymes, on the behavior of rationally designed (targeted) drugs for cancer therapy.
Specifically, I study how these systems affect the pharmacokinetics and tissue distribution of various CDK inhibitors using in vitro and in vivo mouse models. Since reliable drug measurements are essential to perform these studies, my projects also focus on developing new bioanalytical methods, using mostly LC-MS/MS for the quantification of these drugs (and metabolites) in biological matrices. Collectively,All the insights generated may help to improve pharmacotherapy regimens using these drugs.