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Alfred Schinkel group
Alfred Schinkel received his Bachelor's degree in
biology/biochemistry (1979) and his Master's degree in biochemistry
(1983, cum laude) from the University of Amsterdam, The
Netherlands. He obtained a Ph.D. in molecular biology in 1989 (cum
laude) from the University of Amsterdam as well.
From 1988 to 1996 he completed postdoctoral fellowships at the
Netherlands Cancer Institute, and then worked during 1996/1997 as a
visiting scientist at the National Cancer Institute of the National
Institutes of Health in Bethesda, Maryland, U.S.A.
From 1997 he worked as a group leader at the Netherlands Cancer
Institute in Amsterdam, obtaining tenure in 2002. He received the
Dutch Galenus Prize 1993 for work on P-glycoprotein and its role in
the blood-brain barrier, and the Antoni van Leeuwenhoek Prize 1994
for his research on the biological role of P-glycoproteins involved
in multidrug resistance.
Current research interests include the physiological,
pharmacological, and toxicological roles of multidrug efflux and
uptake transporters, and of multidrug metabolizing enzymes.
Techniques used include generation and characterization of knockout
and transgenic mouse strains for these multidrug detoxifying
proteins, and development and utilization of in vitro models to
study these systems. The insights and tools obtained allow
optimization of the development of new drugs and drug
administration regimens, in order to maximize therapeutic efficacy
and minimize toxicity of drug therapy. Over 150 primary research
papers have been published since 1983, resulting in an h-index
>70 (as of 2013).