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Peter Peters group

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Peter Peters

Group leader

Personal details

Experience

Peters obtained his PhD from Utrecht University, where he analyzed the ultrastructure of MHC class II antigen processing and discovered the 'MHC class II compartment' (MIIC) (Peters PJ et al., Nature, 1991, Peters PJ et al., J Exp Med 1995) and studied exocytosis of cytotoxic mediators in T cells. He established that secretory granules are of lysosomal nature (Peters PJ et al., J Exp Med. 1991). Peters joined the group of Rick Klausner at the National Institute Health in Bethesda, USA and identified ARF6 as a regulator for endocytosis (Peters PJ et al., J Cell Biol. 1995). In 1998, he became Principal Investigator at the Netherlands Cancer Institute and was appointed as professor at the Free University of Amsterdam. His long-term focus is on understanding the molecular machinery and organization of molecular sorting within the endocytic membrane system of a cell (D'Souza-Schorey C et al., J Cell Biol. 1998, Peters PJ et al., Nature Cell Biol. 2002, van der Wel NN et al., Mol Biol Cell. 2003, Peters PJ et al., J Cell Biol. 2003 and Mironov A Jr et al, J Neurosci. 2003). Cryo immunogold-EM methods of aldehyde-fixed cells are the main techniques applied, allowing the subcellular detection of gene products at the highest resolution (Van der Wel N at al., Cell. 2007, Godsave SF et al., J Neurosci. 2008 and Peters PJ, Pierson J. Methods Cell Biol. 2008. Review). In addition, Peters' lab is currently improving the ultrathin cryosectioning of native unfixed cells for high-resolution 3D cryo-electron tomography to visualize molecular machines in the context of organelles. Peters' lab consist of 9 scientists and 4 technicians.

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