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Sjoerd Klarenbeek, DVM Dipl ECVP group

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Sjoerd Klarenbeek, DVM Dipl ECVP

PhD student, Laboratory animal pathologist

Personal details

Experience

I study PI3K signaling in invasive lobular carcinoma (ILC). In this type of breast cancer, adherens junctions are disrupted, associated with loss of E-cadherin. Normal mammary epithelial cells do not survive without E-cadherin. Activation of the PI3K signaling network is frequently observed in ILC, and may rescue E-cadherin deficient cells and drive proliferation. We are using genetically engineered mice to study the pathogenesis of ILC, and to explore PI3K signaling as a therapeutic target.
As a pathologist I strive to support and collaborate in many exciting scientific projects at the NKI.

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