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Jacqueline Jacobs group

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Jacqueline Jacobs

Group Leader

Personal details

Experience

Dr. Jacqueline Jacobs studied Biology at the University of Nijmegen, with specialization in Medical Biology, and received her Masters degree in 1996 with honors (cum laude). During her PhD studies at the Netherlands Cancer Institute with Dr. Maarten van Lohuizen she investigated the underlying basis for the oncogenic activity of the Polycomb-group gene BMI1. She identified the INK4a/ARF tumor suppressor locus as a critical target of transcriptional repression by BMI1, through which BMI1 controls cell proliferation, replicative lifespan, apoptosis and oncogenic transformation.

Subsequently Jacqueline developed genome-wide functional genetic screens to identify novel suppressors of INK4a/ARF controlled cellular senescence and identified TBX2 as a novel immortalizing oncogene that directly represses the p19ARF promoter and is amplified in human breast cancer.

For the research during her PhD Jacqueline was awarded the Antoni van Leeuwenhoek Award 1999. In 2000 she received her PhD degree with honors (cum laude) from the University of Utrecht. Until the end of 2001 she continued working as a postdoc with Dr. Maarten van Lohuizen. Next to further characterizing the role of BMI1 and TBX2 in senescence and transformation, she performed in vitro transformation screens to identify novel genes and pathways that collaborate with MYC or RAS oncogenes to promote anchorage-independent growth.

In January 2002 Jacqueline joined the lab of Prof. Dr. Titia de Lange at the Rockefeller University in New York, USA. As a Dutch Cancer Society (DCS) fellow she studied the mechanisms by which telomeres protect chromosome ends and regulate replicative life span. In July 2004 Jacqueline returned to the Netherlands Cancer Institute to continue working on telomeres independently, first as senior postdoctoral fellow, since 2006 as research associate (project leader) and since 2008 as junior group leader.

In 2012 Jacqueline became a tenured research group leader at the Division of Molecular Oncology and was selected as EMBO Young Investigator by the European Molecular Biology Organization.

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