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Jacqueline Jacobs group
Dr. Jacqueline Jacobs studied Biology at the University of
Nijmegen, with specialization in Medical Biology, and received her
Masters degree in 1996 with honors (cum laude). During her PhD
studies at the Netherlands Cancer Institute with Dr. Maarten van
Lohuizen she investigated the underlying basis for the oncogenic
activity of the Polycomb-group gene BMI1. She identified the
INK4a/ARF tumor suppressor locus as a critical target of
transcriptional repression by BMI1, through which BMI1 controls
cell proliferation, replicative lifespan, apoptosis and oncogenic
Subsequently Jacqueline developed genome-wide functional genetic
screens to identify novel suppressors of INK4a/ARF controlled
cellular senescence and identified TBX2 as a novel immortalizing
oncogene that directly represses the p19ARF promoter and is
amplified in human breast cancer.
For the research during her PhD Jacqueline was awarded the
Antoni van Leeuwenhoek Award 1999. In 2000 she received her PhD
degree with honors (cum laude) from the University of Utrecht.
Until the end of 2001 she continued working as a postdoc with Dr.
Maarten van Lohuizen. Next to further characterizing the role of
BMI1 and TBX2 in senescence and transformation, she performed in
vitro transformation screens to identify novel genes and pathways
that collaborate with MYC or RAS oncogenes to promote
In January 2002 Jacqueline joined the lab of Prof. Dr. Titia de
Lange at the Rockefeller University in New York, USA. As a Dutch
Cancer Society (DCS) fellow she studied the mechanisms by which
telomeres protect chromosome ends and regulate replicative life
span. In July 2004 Jacqueline returned to the Netherlands Cancer
Institute to continue working on telomeres independently, first as
senior postdoctoral fellow, since 2006 as research associate
(project leader) and since 2008 as junior group leader.
In 2012 Jacqueline became a tenured research group leader at the
Division of Molecular Oncology and was selected as EMBO Young
Investigator by the European Molecular Biology Organization.