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Tatjana Heidebrecht



After a three year training as a research assistant at the University of Bielefeld, I took a new challenge in the laboratory of A. Perrakis, to work on the JBP1 project. The JBP1 protein binds to DNA that contains the unusual DNA base J, that is essential for survival in many protozoan pathogens. In the last years I crystallized the DNA-binding domain of JBP1 and I characterized it extensively by biophysical methods. A remaining challenge is to determine the structure of full-length JBP1 and understand its relationship with the human TET enzymes that are involved in myeloid leukemia.