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Santiago Gisler,MSc

Ph.D Student

Experience

I am currently investigating the consequences of Polycomb group (PcG) inhibition in tumor cells to uncover novel functions of PcG mediated repression and possible resistance mechanisms. For this I make use of a high throughput, loss-of-function screening strategy in near haploid, human leukemia cell line. By blocking PcG activity by RNAi or pharmacologically, using Bmi1 and Ezh2 inhibitors alone or in combination with other epigenetic inhibitors, I screen for gene functionality capable of bypassing this repression.