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Olimpia Allessandra Buoninfante group

Buoninfante, Alessandra

Olimpia Allessandra Buoninfante

Ph.D. student

Personal details

Experience

I am graduated in Pharmaceutical Biotechnology and conducted my training at "Sapienza" University of Roma and at University of Groningen, studying molecular mechanisms and main factors involved in development of neurodegenerative diseases such as Alzheimer's disease. My PhD project is focused on exploring DNA damage tolerance (DDT) in as a drug target for chemosensitization and a mechanism of chemoresistance. Since effective DDT depends on site-specific PCNA-ubiquitination, I will prohibit this site-specific ubiquitination process at genetic and biochemical levels in cell lines and in mouse tumors models. The aim of my work is to reveal the relevance of DDT as a drug target for cancer treatment and cancer progression.

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