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Bruens, Lotte

Lotte Bruens

Ph.D. Student


After obtaining my Master degree in "Cancer, Stem Cells and Developmental Biology" at Utrecht Univeristy, I joined the group of Jacco van Rheenen in 2014 to start my PhD. I am also part of the Hugo Snippert group at the UMC Utrecht.

My projects mainly focus on homeostasis in the intestinal epithelium and how the epithelium copes with aberrations in this homeostasis. Using intravital microscopy I uncovered a process called crypt fusion, an almost exact reversal phenomenon of crypt fission, during which two crypts fuse into one daughter crypt. I am currently investigating which mechanisms underlie crypt fission and fusion. In addition, I am looking at the effect of calorie restriction on intestinal homeostasis.