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Piet Borst group


Piet Borst

Personal details


Biographic sketch

Piet Borst studied medicine in Amsterdam, where he also obtained a PhD in biochemistry with Bill Slater, studying the properties of mitochondria in cancer cells. He then spent 2 years in New York University with Severo Ochoa, where he studied replication of RNA bacteriophages in E. coli with fellow-postdoc Charles Weissmann. He returned to Amsterdam to become Professor of Biochemistry and Molecular Biology in Amsterdam University, where he worked on the biogenesis of mitochondria and other cell organelles in a variety of organisms.

In 1983 he became director of research of The Netherlands Cancer Institute/Antoni van Leeuwenhoek Hospital, where he continued his research on mechanisms of antigenic variation in trypanosomes and started a new project on mechanisms of drug resistance in cancer cells. In 1999 he stepped down as director, but continued his research in the lab, mainly on drug resistance, the physiological role of ABC-transporters and on DNA base J in trypanosomatids. In 2015 he closed his lab, but he remains an active NKI staff member.

Piet Borst is a member of the Academia Europaea; a foreign associate of the National Academy of Sciences (US); a foreign honorary member of the American Academy of Arts and Sciences (US); a foreign member of the Royal Society (GB); and a foreign honorary Commander of the British Empire (CBE).




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