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Adamopoulos, Nassos

Nassos Adamopoulos

Ph.D. student


I am interested in the role of lysophosphatidic acid (LPA) in tumor progression, angiogenesis and metastasis. Former structural studies in the group, have established the role of Autotaxin in LPA production and signaling. Recently, two new membrane proteins, members of the Glycerophosphodiester phosphodiesterase (GDE) family, which can produce LPA intracellularly were identified. Using structural biology tools, I am trying to understand the molecular mechanism of GDEs and characterise that new LPA generation pathway.