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Aarsman, Ivette

Ivette Aarsman, MSc

Ph.D. student


I graduated from the VU Amsterdam in August 2018 with majors in Molecular Cell Biology and Biochemistry. I started my PhD in September 2018 at the NKI under supervisor of Titia Sixma.

The focus of my project is the deubiquitinating enzyme USP48. USP48 counteracts the ubiquitinating activity of BRCA1 on the H2A histone tail. The aims of my project are to obtain the structure of USP48 and/or related proteins complexes, to determine the molecular mechanism of the site-specific activity of USP48 on a minimal substrate and finally to generate separation-of-function mutants deficient for specific aspects of USP48 regulation.