Webinar by Julio Aguirre-Ghiso
Disseminated cancer cell dormancy: a homeostatic seed and soil partnership
Icahn School of Medicine at Mount Sinai, New York City, USA
Host: Claire Vennin
Julio A. Aguirre-Ghiso, PhD, is a Professor of Medicine at the Icahn School of Medicine at Mount Sinai. His work focuses on understanding the biology of residual cancer cells that persist in a dormant state after initial therapy. His research team led a paradigm shift, revealing novel cancer biology that diverges from the notion that cancer is perpetually proliferating. They discovered that reciprocal crosstalk between disseminated tumor cells and the microenvironment regulates the inter-conversion between dormancy and proliferation. This knowledge enables targeting minimal residual disease before it becomes clinically detectable and thus preventing recurrences. Their research is revealing ways to maintain residual cancer dormancy, kill dormant cancer cells, and utilize markers to determine the dormant or active state of disseminated disease.