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Tumor Biology & Immunology

Divisions

Groups within research area Tumor Biology & Immunology

JannieBorst.jpg

Jannie Borst

Division
Tumor Biology & Immunology
Specialisation
Deciphering molecular mechanisms that govern the T cell response

Introduction

Our research focuses on molecular mechanisms that govern the T cell response. We study the mechanism of action of TNF receptor family members that provide costimulatory signals impacting on T cell survival and death, metabolism, effector- and memory function.

More about the Jannie Borst group

Akkari, Leila

Leila Akkari

Division
Tumor Biology & Immunology
Specialisation
Macrophage Dynamics in Cancer Treatment

Introduction

Over the past several decades, pioneering genetic discoveries have shed light on the mechanisms of cancer progression by characterizing the oncogenes and tumor suppressors driving malignancies. However, translating this knowledge into effective therapeutic options has only been partially successful as tumor progression relies on more than genomic alterations, and cancers also evolve within a tissue microenvironment. Thus, to impact therapeutic outcome, our understanding of cancer dynamics and diversity must not solely view cancer cells as the fundamental unit, but as part of an integrated and reactive system centered around heterotypic communication with their environment.

More about the Leila Akkari group

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Karin de Visser

Division
Tumor Biology & Immunology
Specialisation
Inflammation and Cancer

Introduction

Welcome to the website of the De Visser laboratory at the Division of Immunology at the Netherlands Cancer Institute in Amsterdam. We study the contribution of the immune system to breast cancer progression, metastasis formation and therapy response. Immune cells and their mediators are abundantly present in the microenvironment of (disseminated) cancer cells. Interactions between cancer cells and different components of the immune system influence tumor outgrowth, metastasis formation and the efficacy of anti-cancer therapy. The exact role of the immune system during these processes is, however, controversial and poorly understood, as both tumor-protective and tumor-promoting properties have been reported.

More about the Karin de Visser group

Heinz Jacobs.jpg

Heinz Jacobs

Division
Tumor Biology & Immunology
Specialisation
Programmed Mutagenesis

Introduction

Heinz Jacobs started as a graduate student at the NKI in 1987, and drawn by its excellent research environment returned in 2002 to establish his own group. The main activities in his laboratory focus on how DNA is mutated during the process of programmed mutagenesis, and its role in the somatic evolution of cancer. Programmed mutagenesis is part of the normal development of specialized immune cells known as B-lymphocytes. B cells generate antibodies that recognize pathogens, and programmed mutagenesis, which involves DNA damage, is essential for the production of a diverse antibody arsenal. DNA damage also leads to mutations and cancer, so understanding the processes involved can provide valuable insights into the cause and treatment of cancer. Our approaches involve basic and advanced molecular genetics, biochemistry, immunology, recombinant mouse genetics, and next generation sequencing.

More about the Heinz Jacobs group

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Hein te Riele

Division
Tumor Biology & Immunology
Specialisation
Genomic instability and cancer

Introduction

Genomic instability is a hallmark of human cancer and can be caused by failing DNA repair mechanisms or deregulated cell cycle control. Our research involves both aspects focusing on (1) the role of the DNA mismatch repair system in mutation avoidance and (2) the role of defective cell cycle checkpoints in promoting genome stability. The principle tools include gene modification in murine embryonic stem cells (ESC) and analyses of the phenotypic consequences in ESCs, mutant mice and cell lines derived thereof.

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Zuur, Lotje

Lotje Zuur

Division
Tumor Biology & Immunology
Specialisation
Head and Neck Cancer Treatment

Introduction

Lotje Zuur is a head and neck surgeon who divides her time between clinical patient care in the Antoni van Leeuwenhoek Hospital and her research at the departments of Cell Biology and Immunology in the Netherlands Cancer Institute. As a clinician she is taking care of head and neck cancer patients who suffer relatively limited survival and substantial toxicity from therapy. Therefore, her research group focusses on exploring personalized novel treatment options for these patients with improved cure rates and better quality of life.

More about the Lotje Zuur group

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