This website uses cookies

This websites contains videos from YouTube. This company uses cookies (third party cookies). If you do not want them to use these cookies, you can indicate so here. However, this does mean that you will not be able to watch videos on this website. We also make use of our own cookies in order to improve our website. We don’t share our data with other parties. Read more about our cookie policy

This website uses cookies to enable video and to improve the user experience. If you do not want to accept these cookies, indicate so here. Read more about our cookie policy

Ga direct naar de inhoud, het hoofdmenu, het servicemenu of het zoekveld.

Psychosocial Research and Epidemiology

Divisions

Groups within research area Psychosocial Research and Epidemiology

FloraVanLeeuwen.jpg

Flora van Leeuwen

Division
Psychosocial Research and Epidemiology
Specialisation
Cancer Epidemiology

Introduction

The cancer epidemiology group of Flora E. van Leeuwen focuses on two principal research lines:

(1) the assessment of the long‑term risks of second malignancy and cardiovascular disease following treatment of Hodgkin's lymphoma, breast cancer, testicular cancer and childhood malignancy and
(2) the assessment of the roles of and hormone-related and genetic risk factors in the etiology of breast and ovarian cancer; Special interest is in late effects of ovarian stimulation for in Vitro Fertilization and cancer etiology in BRCA1/2 families.

Epidemiologic methods are combined with molecular analyses a) to examine gene-environment and gene-treatment interactions, and b) to differentiate risk factors for cancer according to specific genetic alterations in the tumor. There is extensive experience in the conduct of large-scale cohort studies and linkage with disease registries.

More about the Flora van Leeuwen group

NeilAaronson.jpg

Neil Aaronson

Division
Psychosocial Research and Epidemiology
Specialisation
Psychosocial Oncology

Introduction

The psychosocial research group of Neil K. Aaronson is pursuing two primary research lines. The first is the development and applications of health-related quality of life (HRQL) assessment tools for use in clinical research and clinical practice. Much of the instrument development work is done in collaboration with the European Organization for Research and Treatment of Cancer Quality of Life Group, and involves generating condition-specific questionnaires (e.g., for breast, colon, prostate cancer) that are brief but sufficiently reliable and valid for use in cancer clinical trials. Implementation of HRQL measures in clinical practice is intended to enhance patient-provider communication and to facilitate optimal clinical management of functional health problems and symptoms. The second primary research line involves the development and testing of behavioral and psychosocial interventions to reduce symptom burden and improve the HRQL of patients with cancer. Examples include cognitive behavioral therapy for treatment-induced menopausal symptoms, physical exercise programs during cancer chemotherapy to minimize fatigue and maximize physical fitness, and internet-based sexual therapy for breast cancer survivors.

More about the Neil Aaronson group

EvelineBleker.jpg

Eveline Bleiker

Division
Psychosocial Research and Epidemiology
Specialisation
Psychosocial oncology

Introduction

This research line is being conducted in close collaboration with the NKI-AVL family cancer clinic. It comprises a number of studies which are focused on three psychosocial themes in genetic counseling for cancer: 1) the uptake and long-term psychosocial impact of genetic counseling and testing and risk-reducing behavior; 2) early detection of psychosocial problems and the development of psycho-educational interventions; and 3) the organization of the psychosocial healthcare for cancer patients and their high risk relatives.

More about the Eveline Bleiker group

WimVanHarten.jpg

Wim van Harten

Division
Psychosocial Research and Epidemiology
Specialisation
Technologies and Services in Oncology

Introduction

In this group three research topics are covered: Early Stage Technology Assessment, Improving Oncology Services and Cancer Rehabilitation.

More about the Wim van Harten group

MichaelHauptmann.jpg

Michael Hauptmann

Division
Psychosocial Research and Epidemiology
Specialisation
Biostatistics

Introduction

Michael Hauptmann is a senior statistician at the NKI and heads the Biostatistics group. His group concentrates on methodological and statistical research and is closely involved with several international cancer epidemiological studies focusing on cancer incidence and exposure to radiation and chemicals. The group performs key statistical analyses, the results of which inform the public as well as regulatory bodies on the appropriate terms of use of potentially harmful substances. They also provide statistical expertise to both the Institute and the Antoni van Leeuwenhoek hospital on diverse topics ranging from experimental to observational studies.

 

More about the Michael Hauptmann group

MattiRookus.jpg

Matti Rookus

Division
Psychosocial Research and Epidemiology
Specialisation
Epidemiology of breast cancer

Introduction

To understand the etiology of hormone-related tumors we initiated three prospective cohort studies.

First, in the national Hereditary Breast and Ovarian cancer study Netherlands (HEBON) we enrolled members of high risk families tested for BRCA1/2 mutations. With this study we actively participate in two international initiatives, the prospective International BRCA1/2 Carrier Cohort Study (IBCCS, coordinated at NKI) and the Consortium of Investigators of Modifiers of BRCA1/2 (CIMBA, epidemiologic part, coordinated at NKI). For instance, inIBCCSwe found an increased risk of breast cancer among BRCA1/2 mutation carriers exposed to diagnostic radiation at an early age. In CIMBA-epi we are investigating if genetic variants may be involved in the well known association between age at menarche and risk of breast cancer. Thus, both hormonal/lifestyle risk factors and genetic alterations are taken into account to assess cancer risks and better understand cancer etiology in high risk families. We aim to develop a risk prediction model that incorporates Dutch baseline cancer risks and hormonal/lifestyle/genetic risk factors, to be used in the clinical genetic practice. HEBON/IBCCS/CIMBA are also a resources for studies on gene-gene and treatment-gene interactions, studies on the late health effects of prophylactic surgeries on breasts and ovaries, and studies on the psychological impact of genetic testing and the subsequent decision-making processes.

Secondly, we focus on thein uteroperiod as the time window of interest by investigating a cohort of 12,000 women exposed to Diethylstilbestrolin utero(DES daughters). We found that the risk of clear-cell adeno carcinoma of the vagina is still increased at higher ages. So far, we did not detect an increased risk of breast cancer among DES daughters. In a third cohort consisting of 59,000 Dutch nurses we investigate the association between shift work and risk of hormone-related cancers. We will examine if variants in clock genes are related with the duration of shift work and if they modify the potential association between shift work and risk of breast cancer.

More about the Matti Rookus group

SanneSchagen.jpg

Sanne Schagen

Division
Psychosocial Research and Epidemiology
Specialisation
Cognition and Cancer

Introduction

Many cancer patients experience cognitive changes during their disease course and following treatment that interfere with their daily life activities. The projects constituting the research line of Sanne Schagen center around the investigation of the incidence, nature, severity and determinants of cognitive problems associated with cancer and its treatments. Identifying patients at risk, and the emotional, cognitive and biological mechanisms associated with these effects, is critical for prevention and treatment.

More about the Sanne Schagen group

Share this page