Vacancy PhD Student
Preclinical Pharmacokinetics - Pharmacodynamics of small
molecule drugs for treatment of cancer.
Your function within the department
One of the research aims of the research group of Olaf van
Tellingen at the Division of Pharmacology is to improve the
predictive value of preclinical murine models of cancer. Although
the work in his team is centered around brain tumors, the scope of
this project will also be on other tumor types. Mouse models of
cancer are central in the development of anticancer therapy.
Unfortunately, promising results observed in preclinical models
often fail to translate to clinical benefit in patients. Although
there likely are several factors that contribute to this lack of
predictivity, one often neglected aspect is the pharmacological
translation from experimental species to patients. In this project,
you will investigate the pharmacokinetic - pharmacodynamic (PK-PD)
relationship of anticancer drugs and their respective targets in
preclinical models. You will focus on the differences in drug
exposure between rodents and humans and drug distribution between
ectopic and orthotopic tumor models. The ultimate aim of the
project is to demonstrate how taking the pharmacological
translation into consideration can improve the predictive value of
preclinical cancer models.
We are seeking an ambitious, highly motivated PhD student with a
strong commitment to science and a keen interest to work at the
intersection of Pharmacology and Medical biology. You are attracted
to interact in a strong team, but capable to work independently.
This work will involve analytical (LC-MS/MS) and biological assays,
in vitro (cell culture) and in vivo (mouse/rat) models. An MSc in
Pharmacology or Oncology and experience with any of these
techniques is advantageous. The possession of or commitment to
acquire an animal license (Art. 9) is mandatory.
You will join a dynamic international research division and
collaborate with scientists and clinicians within and outside the
NKI-AVL with expertise in different disciplines. Graduate students
at the NKI participate in the education program of the Oncology
Graduate School (OOA) Amsterdam. Supervision and promotion of
career will be carried out by experts in their respective
Your career opportunities and terms of
Your temporary employment is for a period of 4 years with a
possible extension of another year. The gross salary per month will
be from € 2,798 to € 3,446, according to the standard PhD scales.
The terms of employment will be in accordance with the CAO
Ziekenhuizen (Collective Labour Agreement for Hospitals) and can be
Amsterdam is a very lively city with many cultural amenities.
The institute is located within a 20 minute tram or bicycle ride
from the city center and within 20 minutes from Schiphol airport by
car, bus or bicycle.
For further information about the position, please contact. dr.
Olaf van Tellingen, Division of Pharmacology (tel. +31 20 512 2792,
e-mail firstname.lastname@example.org). To
apply for the position, please follow the link below.
Olaf van TellingenGroup leaderApply for the position
Pint of Science Festival
The Pint of Science festival aims to deliver interesting, fun,
relevant talks on the latest science research in an accessible
format to the public - all in the pub! During the upcoming
edition on May 20th, Paul Slangen, Mark de Gooijer and Inge
Verbrugge will be hosting an evening themed 'The Brain: can we
beat this obstacle course?'.
The event is freely admissible, but registration is required and
can be done by following the link below. We hope to see you all
The Brain: can we beat this obstacle course?