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Molecular Pathology: Wilbert Zwart

Research interest: Hormone-Associated Cancers

As a lab, we position ourselves as a multidisciplinary translational endocrinology group. As such, we operate at the intersection of genomics, pathology, cell biology and molecular pathology. I strongly believe that combining specialities from different research fields is key for innovative translational science in cancer research. The hormone-related mechanisms in transcriptional regulation of breast cancer, endometrial cancer and prostate cancer are tightly linked, creating many opportunities for synergy between the research lines in the lab. The central theme of our research projects revolves around personalized cancer treatment, where we aim to identify novel biomarkers and to unravel the underlying biological mechanisms. 

 

Co-workers

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Xanthippi Alexi, Ph.D.

Postdoctoral fellow

Experience

I obtained my doctorate on extracellular matrix and growth factor cross-signalling under the supervision of dr. Fedor Berditchevski and dr. Elena Odintsova (Universtity of Birmingham, UK). I then joined IBRB (Athens, Greece) as a postdoctoral fellow for dr. Michael N Alexis, investigating the effect of natural and synthetic compounds on estrogen receptor biology. Since the beginning of 2010 I've worked at the Netherlands Cancer Institute first within the laboratory of Rob Michalides and later of Wilbert Zwart. My current projects focus on anti-estrogen resistance and the role of post-translational modifications and growth factor signaling in this event.

 

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Marjolein Droog, MSc

Ph.D. Student

Experience

I finished my bachelor in 2009 with an internship at the Leiden University Medical Centre. Next, I completed a master at the VU University Amsterdam in 2011 during which I performed two internships, one at the VU University Amsterdam and a final internship at the Cancer Research UK, Cambridge Research Institute. I started as a PhD student at the Netherlands Cancer Institute in the group of Wilbert Zwart in 2011. My main project involves a molecular understanding of the agonistic effect of tamoxifen in endometrial cancer development and unraveling what enables the Estrogen Receptor in different cell types.

 

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Koen D Flach, MSc

Ph.D. Student

Experience

I performed my Master Oncology training at the VU University Medical Center, Amsterdam during 2010-2012. My first internship was at the Cancer Center Amsterdam in 2011 in the group of Prof. dr. G.J. Peters. My second internship was at the Netherlands Cancer Institute, Amsterdam in the group of Wilbert Zwart, where I, after finishing my Master's, started as a PhD-student. At the moment I'm working on a genomics-based tool to predict the tamoxifen response in ER-positive breast cancer tumors. Additionally I'm studying the spatial and temporal regulation of the ERα-transcription complex.

 

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Joosten, Stacey

Stacey Joosten, MSc

Ph.D. Student

Experience

In 2012, I obtained a bachelor degree in biomedical sciences at the VU University of Amsterdam. My bachelor internship at the Hubrecht Institute inspired me to specialize in oncology. I enrolled in the master Oncology at the VU University Medical Centre, for which I performed two additional internships at the Cancer Centre Amsterdam and the NKI-AVL. I also pursued a degree in healthcare policy.

Recently, I joined the lab of Wilbert Zwart as a PhD student. In collaboration with the group of Sabine Linn, we aim to develop a predictive profile for endocrine treatment in breast cancer.  

 

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Yongsoo Kim

Postdoctoral fellow

Experience

I studied computer science during my undergraduate study at Pohang University of Science and Technology (POSTECH), South Korea. During my Ph.D training, I participated in systems biology lab (Prof. Daehee Hwang) and machine learning lab (Prof. Seungjin Choi), and my research is dedicated to computational systems biology.

I joined labs of Wilbert Zwart and Lodewyk Wessels to contribute to cancer research computationally. My project is funded through a Alpe d'HuZes/ KWF Bas Mulder project awarded to Wilbert, aimed to identify novel applications of existing hormonal drugs.

 

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Mayayo Peralta, Isabel

Isabel Mayayo Peralta

Ph.D. Student

Experience

I graduated in Medical Biochemistry from the University of Navarra (Spain). Next, I obtained my Master's degree in Medical Biology from the University of Amsterdam. Being interested in oncological research, I joined the lab of Dr Wilbert Zwart as a PhD student in December 2016.

In my project, I will focus on progressive metastatic breast cancer. With this project we aim to gain new insights into the proteomic, genomic and epigenetic landscape of the metastatic disease in relation to personalised therapeutic approaches.

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Ekaterina Nevedomskaya

Postdoctoral fellow

Experience

I completed my PhD in metabolomics under supervision of Prof. Dr. André Deelder and Dr. Oleg Mayboroda at the Leiden University Medical Center. Afterwards I stayed as a post-doc in the same group, spending time as a visiting researcher in the group of Dr. Hector Keun (Imperial College London) working on multi-omics data integration for understanding metabolism control in cancer.  Pursuing my interest in cancer biology I joined the labs of Wilbert Zwart, Lodewyk Wessels and Andre Bergman as a bioinformatics postdoc. My main project is analysis of androgen receptor genomics data for elucidation of treatment resistance in prostate cancer.

 

 

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Laurel Schunselaar

Ph.D. Student

Experience

In October 2012, I obtained my master degree in Technical medicine.
I performed my master internship, about primary tumor cultures of malignant pleural mesothelioma (MPM), in the lab of Sjaak Neefjes. After my master internship, I continued working at the project as a phd-student. Since the move of Sjaak Neefjes to the LUMC,  I'm working in the lab of Wilbert Zwart.
My main project is about personalized medicine for patients with mesothelioma. With chemosensitivity screens on primary tumor cultures we determine second line treatment for patients. 
This project is in collaboration with the thoracic oncology department, under supervision of Paul Baas and Sjaak Neefjes.

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Suzan Stelloo, MSc

Ph.D. Student

Experience

I received my Bachelor degree in molecular biology from the hogeschool Utrecht, and then I graduated from the Utrecht University. During the master program Cancer Genomics & Developmental biology I performed an internship at the UMC Utrecht in the group of dr. Derksen and a second in the lab of Prof. Melino at the University Tor Vergata, Rome. In February 2013, I started as a PhD student in the lab of Wilbert Zwart & André Bergman. My work focuses on integrative androgen receptor genomics as a readout for recurrence risk and treatment resistance of prostate cancer.

 

 

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Zhu, Yanyun

Yanyun Zhu

Ph.D. Student

Experience

I did my master in Wageningen University in food safety from 2013 to 2015. During my study, I followed my interest in oncology and did both of my master thesis and internship in this field, which studied the mutation of TP53 gene and the ERα positive breast cancer, in the toxicology department (the group of professor Ivonne Rietjens) of Wageningen University. 
Motivated by my strong interest in oncology, I decided to do a Ph.D. after I finished my master. In July 2016, I joined the groups of Wilbert Zwart and Andre Bergman as a Ph.D. student. My project focusses on biomarker discovery for response to Enzalutamide treatment in prostate cancer.

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Key publications View All Publications

  • Androgen receptor profiling predicts prostate cancer outcome

    (2015) EMBO Mol Med. Sep 27. pii: e201505424. doi: 10.15252/emmm.201505424. [Epub ahead of print]

    Stelloo S, Nevedomskaya E, van der Poel HG, de Jong J, van Leenders GJ, Jenster G, Wessels LF, Bergman AM, Zwart W.

    Link to PubMed
  • Hallmarks of aromatase inhibitor drug resistance revealed by epigenetic profiling in breast cancer

    (2013) Cancer Res. Nov 15;73(22):6632-41. doi: 10.1158/0008-5472.CAN-13-0704

    Jansen MP, Knijnenburg T, Reijm EA, Simon I, Kerkhoven R, Droog M, Velds A, van Laere S, Dirix L, Alexi X, Foekens JA, Wessels L, Linn et al.

    Link to PubMed
 
 

Recent publications View All Publications

  • The Estrogen Receptor α-Cistrome Beyond Breast Cancer

    (2016) Mol Endocrinol. Oct;30(10):1046-1058.

    Droog M, Mensink M, Zwart W.

    Link to PubMed
  • The Effects of Enzalutamide Monotherapy on Multiparametric 3T MR Imaging in Prostate Cancer

    (2016) Urol Case Rep. May 26;7:67-9. doi: 10.1016/j.eucr.2016.04.010. eCollection 2016 Jul.

    Van der Roest RC, van Houdt PJ, Heijmink SW, de Jong J, Bergman AM, Zwart W, van der Heide UA, van der Poel HG.

    Link to PubMed
 

Contact

  • Office manager

    Mirna Ekelschot - van Diermen

  • E-mail

    m.v.diermen@nki.nl

  • Telephone Number

    +31 20 512 9127

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'Our goal is to fully personalize hormonal cancer treatment. To know which drug to give and to understand why it works. Support our research to help us achieve this goal.'

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