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Molecular Genetics: André Bergman, Ph.D

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André Bergman, Ph.DGroup Leader

About André Bergman

Research interest

Andre Bergman divides his time between treating cancer patients at the Antoni van Leeuwenhoek hospital, and working in the laboratory at the adjacent NKI, where he researches the mechanisms underlying prostate cancer development. Prostate cancer is the most prevalent malignant disease in men. It develops through distinct stages, and there is emerging evidence that the tumor microenvironment plays an important role in driving progression through the different stages. The Bergman group investigates the contribution of the microenvironment in prostate cancer development using both cancer models in the laboratory, as well as human prostate cancer. Their goal is to identify new mechanisms and targets that could be used to develop more effective therapeutic approaches.

Co-workers

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Bianca Cioni

Ph.D Student

Experience

I studied Medical Biotechnology at University of Florence in Italy. Following a Master in Molecular Biotechnology at the University of Birmingham in UK, I started working at the NKI as a PhD student from October 2013. My project is funded by the Marie Curie European research grant for the Initial Training Network on Tumor Infiltrating Myeloid Compartment Cells (TIMCC) and is supervised by André Bergman and Jan Paul de Boer. In this project we aim to analyze the myeloid cells infiltration in the tumor microenvironment of human tissues from Prostate and Head and Neck cancer. We will mainly focus on macrophage differentiation in M1 or M2 subtype. Understanding the mechanism of  myeloid cell regulation in the microenvironment and its relation with tumor progression might be critical for the development of new treatment modalities.

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Suzan Stelloo, MSc

Ph.D. Student

Experience

I received my Bachelor degree in molecular biology from the hogeschool Utrecht, and then I graduated from the Utrecht University. During the master program Cancer Genomics & Developmental biology I performed an internship at the UMC Utrecht in the group of dr. Derksen and a second in the lab of Prof. Melino at the University Tor Vergata, Rome. In February 2013, I started as a PhD student in the lab of Wilbert Zwart & André Bergman. My work focuses on integrative androgen receptor genomics as a readout for recurrence risk and treatment resistance of prostate cancer.

 

 

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Jeroen Kneppers

PhD student

Experience

As a 2016 MSc Molecular Life Sciences graduate from Wageningen University (WUR), I have investigated gene editing tools such as CRISPR-Cas12a in the Zhang lab at the Broad Institute, Cambridge, USA. My current technical expertise are in Molecular Biology, Next Generation Sequencing (NGS) and CRISPR. My research project at the NKI focuses on interactions of nuclear receptors in the prostate cancer microenvironment. Eventually, it is my hope that our findings results in the discovery of better prognostic biomarkers, which will enable improved personalized treatment of patients.

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Simon Linder

PhD student

Experience

I obtained my Bachelor's as well as my Master's degree in Biomolecular Engineering from the Technical University of Darmstadt, Germany. Within my Master's studies I have performed an internship at the Netherlands Cancer Institute in the lab of René Medema. In June 2017, I joined the groups of Wilbert Zwart and André Bergman as a Ph.D. student. Here, my project focuses on genome-wide profiling of Androgen Receptor action in clinical specimens, in search of biomarkers for prognostication and treatment selection in prostate cancer.

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Research updates View All Updates

  • We are currently investigating the role of the adaptive immune system in initiation and development of prostate cancer in models of cancer and in human prostate cancer material.

Key publications View All Publications

  • Cabazitaxel in patients with metastatic castration-resistant prostate cancer: results of a compassionate use program in the Netherlands

    Clin Genitourin Cancer. 2013

    Wissing MD, van Oort IM, Gerritsen WR, van den Eertwegh AJ, Coenen JL, Bergman AM, Gelderblom H.

    Link to Pubmed
  • Pim1 regulates androgen-dependent survival signaling in prostate cancer cells.

    Urol Int. 2010; 84: 212-20

    van der Poel HG, Zevenhoven J, Bergman AM.

    Link to Pubmed
 
 

Recent publications View All Publications

  • Neoadjuvant taxane-based combination chemotherapy in patients with advanced penile cancer.

    Clin Genitourin Cancer. 2015 Feb;13:44-9

    Djajadiningrat RS, Bergman AM, van Werkhoven E, Vegt E, Horenblas S.

    Link to Pubmed
  • Nieuwe therapeutische mogelijkheden voor de behandeling van gemetastaseerd prostaatcarcinoom

    Ned. Tijdschr. Oncologie.2015, 12: 225-231

    AM Bergman

    Link to article
 

Contact

  • Office manager

    Marij Degen

  • E-mail

    m.degen_AT_ nki.nl

  • Telephone Number

    +31 (0)20 512 9134

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