Diagnostic Oncology: Gerrit Meijer
Translational Gastrointestinal Oncology
- Anne BolijnTechnician
- Beatriz CarvalhoPhD, Associate staff scientist / principal investigator
- Evert van den BroekPhD Student
- Gosia KomorPhD Student
- Janneke van DenderenResearch associate / project manager
- Linda BoschPostdoctoral fellow
- Marianne TijssenTechnician
- Mariska BierkensPostdoctoral fellow
- Meta van Lanschot
- Pauline van Mulligen
- Pien Delis-van Diemen
- Remond FijnemanPhD, Associate staff scientist / principal investigator
- Sanne Martens - de KempPostdoctoral fellow
- Annemieke HiemstraDatamanager, Msc.
- Jacob RousseauClinical Programmer
- Sander de RidderBioinformatician
- Alex HennemanBioinformatician
I have completed my Bachelor of Science in Biochemistry in 2005 at the HAN HLO in Nijmegen. After graduating I started working as a research technician at the Canisius-Wilhelmina Ziekenhuis in Nijmegen where I was involved in the research group at the department of pathology, with a focus on lung cancer tissues and sputum. In 2007 I started working in the tumor profiling group of Gerrit Meijer of the pathology department at the VUmc, Amsterdam, on the subject colorectal cancer, with a main focus on miRNAs. In 2015 I moved to NKI, continuing the investigation of colorectal cancer in tissues, feces, cell lines and organoids. Practically I am involved in the setup, planning and execution of divers molecular and functional experiments. I have experience in DNA/RNA isolations, (q)(RT-)PCRs, MSPs, MLPA, basic and advanced cell culture (including organoid culture), sequencing, sample processing.
PhD, Associate staff scientist / principal investigator
I'm a molecular biologist with interest in colorectal adenoma to carcinoma progression and in the use of this knowledge for identification of better markers for early detection of colorectal cancer. After completing my PhD in 2001 in the area of gastric cancer, at the University of Porto (Portugal), I started a postdoctoral position at the University of Groningen, still in the area of gastric cancer. In 2003, I moved to the colorectal cancer research field, within the group of Gerrit Meijer. Next to understanding biology and discovery of biomarkers, our research focuses on the translation of these findings in a clinical setting.
Evert van den Broek
I started my PhD in the group of Gerrit Meijer in 2011 after I studied Medicine at the VU University medical center. My PhD-project is mainly focusing on identification of genes that are affected by structural variants in colorectal cancer and aims to investigate their biological and clinical relevance.
I have started to work on my PhD project in September 2014. I work on integration of RNA-seq and proteomics data to detect aberrant splicing in colorectal cancer. It's a joined effort of Tumour Gastroenterology Oncology group at the Netherlands Cancer Institute and Oncoproteomics Laboratory at VU University medical centre. Before starting my PhD I have obtained a double MSc degree in Bioinformatics and Systems Biology at Vrije Universiteit Amsterdam and Warsaw University in Poland in 2014.
Janneke van Denderen
Research associate / project manager
After completing my PhD at the Erasmus University in Rotterdam I focused on management and education in VUmc. I was involved in the development of the Oncology Research Institute at VUmc, the Oncology Graduate School Amsterdam and initiated the Master Oncology at VUmc. Subsequently I was projectmanager in the department of Pathology at VUmc of two CTMM projects respectively on colon cancer (DeCoDe) and lung cancer (AIRFORCE). As of April 2015 I am projectmanager of the Stand Up to Cancer project MEDOCC (Molecular Early Detection of Colorectal Cancer) at NKI.
I am a molecular biologist with special interest in translational oncology and translational bioinformatics. During my PhD project at the VU University Medical Center, I have addressed multiple problems related to colorectal cancer, using a wide range of different methods. My work focused on the identification and validation of molecular markers for the early detection of colorectal cancer in stool. This was followed in 2013 by postdoctoral work at the same research group, where I was responsible for all methylation-based studies within the research program.
As a KWF postdoctoral fellow I am continuing my work in translational colorectal cancer research and developing my self in the field of translational bioinformatics.
Google Scholar: http://goo.gl/pWKJS0
After I received my bachelor degree in 1999 I worked for two small biotech companies in the field of Immunology. In 2003 I moved to the VUmc where I worked at the Micro array Facility helping to set up the Facility. In 2006 I moved to the research group of Gerrit Meijer at the VUmc and in April 2015 I moved to NKI.
My expertise lies mainly in molecular biology techniques, micro biology and cell culture/functional analysis
I am a molecular biologist interested in (epi)genetic alterations underlying disease development. After my PhD I started working as poweruser for the Center for Translational Molecular Medicine, Translational Research-IT (CTMM-TraIT) project. The project aim is to provide sustainable data-management solutions for translational research data types. I have evaluated tools for their capability of accommodating research data and work with IT developers to improve the chosen tools. I am also a data consultant and member of a data-team, which is tasked with getting data of TraIT customers onto the data-integration platform for easy view and query.
Meta van Lanschot
Pauline van Mulligen
Pien Delis-van Diemen
After I received my bachelor degree in 2002 at the Hogeschool of Utrecht I worked for 2 years in the group of Prof. Dr. Peter Snijders at the molecular Pathology in VUmc. In 2004 I switched to the tumor profiling group of Prof. Dr. Gerrit Meijer and in April 2015 I moved to the NKI.
I have experience in basic and advanced cell culture (including organoid culture), IHC and IF stainings, isolations of samples (DNA/RNA and Protein) and Western Blot.
PhD, Associate staff scientist / principal investigator
After completing my PhD studies in cancer genetics at this institute (1997) I investigated tumor biology during my postdoctoral period at Harvard Medical School (Boston, USA) and the VU University Medical Center (Amsterdam). In 2004 I joined the group of prof.dr. Gerrit A. Meijer, where my research focused on translational gastrointestinal oncology. I aim to identify and validate diagnostic, prognostic, and predictive biomarkers for colorectal cancer, and to translate these findings into clinical applications. In addition, I am involved in (inter)national translational research IT infrastructure projects that aim to facilitate translational cancer research.
Sanne Martens - de Kemp
The focus of my research is on the colorectal adenoma-to-carcinoma progression. In a joined project with the Oncoproteomics Lab at the VU University Medical Center, I am analyzing the phosphorylation profile of a large series of colorectal adenomas and carcinomas. The candidate drivers of adenoma-to-carcinoma progression will be functionally validated in vitro and in vivo using genetically manipulated adenoma-derived organoids.
I am a molecular biologist by training and I obtained a Master's degree in Oncology. Before joining the NKI, I worked in the field of head-and-neck cancer at the VU University Medical Center. I received my PhD on genome-wide siRNA screens, miRNA screens, cisplatin response prediction and cancer stem cells.
After obtaining a bachelor's degree in Medical Imaging and Radiation Oncology (2008) followed by a master's degree in Oncology (2011), I have been working as research technician and PhD student on the early detection of colorectal cancer at the VUmc Pathology department in Amsterdam. During this time I additionally worked as editorial assistant for the Cellular Oncology journal and project manager for the European NSCLC ALK IHC+ registry study. Currently I'm involved in the CTMM-TraIT project as data manager and the NWO Roadmap project BBMRI-NL2.0 as warehouse task leader within the Biobank IT Infrastructure work package.
OpenClinica developer / administrator. Responsible (with other colleagues) for the maintenance of the openclinica.nl web-sites. Amongst others I'm a Certified Information Systems Security Professional (CISSP), Certified Scrum-master and Java-developer.
Sander de Ridder
After receiving my Master's degree in Computer Science I worked as a consultant for nearly two years. To get more involved in the field of biology, I went back to university, where I did a Master's in Bioinformatics.
Recently, I worked on the CTMM TRACER project for five years. I designed complex eCRFs, created studies in OpenClinica and did ETL work to convert and upload clinical data. Furthermore, I developed tools to aid this process and assisted the IDP group by creating analysis scripts. After TRACER, I worked at a commercial company, where I did cBioPortal development and data uploads.
I received my Ph.D. degree in Theoretical High Energy Physics from the Vrije Universiteit in 2005. Subsequently, I worked as a bioinformatician at the Center for Proteomics and Metabolomics of the Leiden University Medical Center. In 2016, I joined the NKI to work on a collaborative project with the OncoProteomics Laboratory of the VU Medical Center, sponsored by a joint Dutch Cancer Society (KWF) project entitled "Signaling pathways involved in colorectal adenomatocarcinoma progression". To this end, I focus on phosphoproteomics data analysis strategies for biomarker discovery.
Pauline van Mulligen
+31 20 512 7998
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