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Cell Biology I

Divisions

Groups within research area Cell Biology I

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Arnoud Sonnenberg

Division
Cell Biology I
Specialisation
Cell-matrix adhesion

Introduction

Arnoud Sonnenberg was trained in several laboratories in the USA and the Netherlands before obtaining his PhD from the University of Amsterdam. In 1990, he joined the Division of Cell Biology at the Netherlands Cancer Institute in Amsterdam, where he became head of the Division in 2003. He has been an editor of the J. Cell Science since 2005. The main objective of his research is to understand the function of integrins in differentiation and migration, and how integrins and associated proteins regulate the assembly of multiprotein complexes at the cell substratum site in normal and pathological conditions.

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Kees Jalink

Division
Cell Biology I
Specialisation
Biophysics of Cell Signaling

Introduction

Kees Jalink is a biophysicist who is interested in designing and developing technologies for tackling diverse biological questions. He has brought many new technologies to the NKI and is an advisor to three companies on the creation of new devices. He often builds prototypes in the lab from individual pieces using sticky tape and then invites industry in to make them user-friendly. His group spends half of its time establishing new techniques and serving as the NKI biophysical center of expertise for those techniques, collaborating and publishing jointly with others. With the other half, they focus on their own research on cellular adhesion mechanisms involved in cancer.

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Wouter Moolenaar

Division
Cell Biology I
Specialisation
Lipid Growth Factor Signaling

Introduction

Phospholipids are best known as the major building blocks of cell membranes, but some lipids play a signaling rather than a structural role. Our group is interested in nature's simplest phospholipid, lysophosphatidic acid (LPA), which we discovered as a lipid growth factor many years ago. Since then, our group has made substantial progress in unraveling how LPA regulates numerous biological processes, including cell migration and proliferation. Our current work focuses on the LPA-producing enzyme autotaxin, specifically its mechanism of action and role in tumor progression. Our ultimate goal is to translate new findings on autotaxin-LPA signaling into more effective anticancer strategies.

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René Medema

Division
Cell Biology I
Specialisation
Cell Division and Cancer

Introduction

René Medema became director of the NKI in 2012, and brought an established research group to the institute. He has extensive experience studying the mechanisms underlying cell division, particularly the molecular checkpoints that control progression of the cell cycle. Many classic anti-cancer drugs kill cells by targeting the cell cycle, for example by damaging DNA or by perturbing assembly of the mitotic spindle, which is required for cell division. René's group aims to gain a clearer understanding of the cellular responses to these drugs in order to better predict drug responses and experimentally test new and potentially more effective anti-cancer strategies.

More about the René Medema group

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