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Biochemistry

Divisions

Groups within research area Biochemistry

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Titia Sixma

Division
Biochemistry
Specialisation
Structural Biology

Introduction

We are interested in the working mechanism of proteins. We use crystallography to obtain snapshots of proteins in atomic detail, to uncover function, such as how one protein activates another. By combining protein structure analysis with biochemical analyses we gain insight into protein action. The group is interested in the signaling processes that regulate DNA function repair, in particular ubiquitination. We study ubiquitin ligases and deubiquitinating enzymes that affect the DNA damage response and the access to DNA, many of which have been linked with cancer. Understanding the relationship between their structure and function can be valuable for designing new and effective anti-cancer drugs.

More about the Titia Sixma group

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Anastassis (Tassos) Perrakis

Division
Biochemistry
Specialisation
Macromolecular Structures

Introduction

Macromolecular structures are critical for understanding the function of proteins and their complexes and to evaluate and develop new drugs. We aim to understand the spatiotemporal control that protein interactions and small domains within the same protein exert on the function of proteins, at the level of the molecular structure and function. Concurrently, the group is developing methods to help the wider scientific community study macromolecules more efficiently by X-ray crystallography.

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Thijn Brummelkamp

Division
Biochemistry
Specialisation
Experimental biomedical genetics

Introduction

Thijn Brummelkamp develops and uses genetic tools to identify and characterize genes that play important roles in human disease. Recently, Thijn's group developed a novel genetic model system based on haploid human cells to enable inactivation of most human genes. They use this approach in a variety of different projects for example to search for cancer cell vulnerabilities or to identify host factors that are hijacked by viruses to enter human cells.

More about the Thijn Brummelkamp group

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