PhD-Student Computational Biology

Function description

The lab of Elzo de Wit is a genomics group with an interest in genome function and dynamics. We aim to strongly integrate wet-lab and computational biology. We use a multitude of genomics methods such as ChIPseq, (single-cell) ATAC-seq and Hi-C to study the interplay between nuclear organization, chromatin states and gene expression.

Project
The human genome in every cell measures roughly 2 meters in length but has to fit in a nucleus that is only 5-10 micrometers in size. To accomplish this the genome is folded in a non-random manner. It is becoming increasingly clear that the folding of the genome critically influences gene expression both in healthy and diseased cellular states. The lab aims to better understand the interplay between the folding of the genome and gene expression processes. For this we use genomics methods such as Hi-C in the context of acutely depleted proteins using the dTAG or AID system. We actively develop computational analysis methods to process these data and integrate them with other genomics datasets such as RNAseq and ChIPseq. The project aims to answer fundamental questions about the interplay between genome organization and gene expression.

Job requirements

We seek an ambitious PhD student with a strong affinity for computational biology and biological problem solving. Strong commitment, proven programming experience, and high motivation and enthusiasm to work together with experimentalists is required.  

Compensation

You will be employed for a period of at least four years, with a possibility for extension. For a PhD student the gross salary per month is € 2.798,- to € 3.375,- according to the PhD student scales of the NKI.
The salary depends on previous experience. The terms of employment will be in accordance with the CAO Hospitals (Collective Labour Agreement for Hospitals).

Contact information

For further information about the position please contact Dr. Elzo de Wit tel. +31 20 512 7864 or e-mail: e.d.wit@nki.nl

Acquisition for this vacancy is not appreciated.

Details

  • Hours per Week: 36
  • Salary level: OIO
  • Education level: WO
Carly  DeSantis

Carly DeSantis

Recruiter
Elzo de Wit

Elzo de Wit

Junior Group leader

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