Molecular Pathology: Jan Schellens
Jan Schellens, M.D. professorGroupleader
- +31 20 512 2446
Research interest: Personalized Cancer Treatment
- Emilie van Brummelen, MScPh.D. Student
- Artur BuryloTechnician
- Mark van Bussel, MScPh.D. Student
- Robin van Geel, MScPh.D. Student
- Linda Henricks, MScPh.D. Student
- Bart Jacobs, MScPh.D. Student
- Ruud van der NollPh.D. Student
- Dick Pluim, BScTechnician
- Willeke Ros, MScPh.D. Student
- Vincent de Weger, MSc M.D.Ph.D. Student
- Willem KeustersMaster Student
Emilie van Brummelen, MSc
I am doing my PhD in Prof. Jan Schellens' research group on the
division of Molecular Pathology. In my research I focus on phase
I/II clinical studies. I finished the Master in Pharmacy and the
Honours Programme of Pharmaceutical Sciences at Utrecht University
in the end of 2013. During my studies, I did an internship at Bayer
Pharma in Berlin, and at several pharmacies and hospitals in the
Netherlands. Next to that I worked on a research project on the
development of polyomavirus-derived virus-like particles by
directed evolution at the group of Pharmaceutics at Utrecht
University. Also I did research on the effect of broccoli on the
CYP2D6 phenotype in vitro and in vivo.
During my studies it became more and more clear that clinical research is one of my main interests. That brought me here to work on clinical trials for my PhD, to learn about all aspects of clinical research.
Mark van Bussel, MSc
In 2013 I finished my Master in Pharmacy at Utrecht University. In my master research project I studied the pleiotropic effects of statins and ACE-inhibitors in patients with COPD at The University of Alabama at Birmingham, United States. Thereafter, I worked as a pharmacist in a hospital pharmacy. I work as a Ph.D. student in the group of Prof. Dr. Jan Schellens. My projects focus on phase I/II clinical studies.
Robin van Geel, MSc
As a PhD-student I work on early phase clinical studies focusing on targeted anti-cancer agents and combination strategies. One of my projects involves a phase I/II study combining a BRAF inhibitor with an EGFR inhibitor in patients with BRAF mutated metastatic colorectal cancer. This experimental therapy is based on preclinical data that suggested that both BRAF and EGFR should be targeted to effectively inhibit growth of BRAF mutated colorectal cancers. Preliminary results suggest that this treatment is very effective in this selected group of patients, with tumor responses in a substantial part of the patients at the expense of very limited adverse events.
Linda Henricks, MSc
As a PhD student in the group of Prof. Jan Schellens the focus of my research is on the safety, feasibility and cost-effectiveness of genotype- and phenotype-directed individualized dosing of fluoropyrimidines. In August 2014 I finished my master in Pharmacy at the Utrecht University cum laude. During my master I did an internship at the University of California in San Francisco where I studied the Ras pathway in colorectal cancer.
Bart Jacobs, MSc
After finishing my Masters in Pharmacy in the end of 2011 (Utrecht University) I started working as a PhD student in the group of Prof. dr. J.H.M. Schellens. My research project is focused on the development and clinical testing of new oral fluoropyrimidine drugs in order to explore implications for chronotherapy. This research is supported by bioanalytical projects in order to develop and validate assays which can be applied in the clinical studies. In addition, to gain more insight in the pharmacology of oral fluoropyrimidines, I'm currently working on the development of a population based pharmacokinetic model for capecitabine.
Ruud van der Noll
I finished my Master in Pharmacy at the University of Utrecht in
2009. After working as a pharmacist for a little while, I decided
to take on a more challenging position and started working as a PhD
student for the Schellens group at the NKI.
My research mainly focuses on several phase I studies in which new compounds or new combinations of existing drugs are given to patients for the first time. In these studies we try to establish what the toxicities are and what the recommended dose is for future studies, but also investigate whether there is evidence of preliminary anti-tumor activity.
Dick Pluim, BSc
I am involved as an independent researcher in the development and validation of non-invasive predictive and pharmacodynamic biomarker assays for monitoring the effect of molecular targeted anticancer agents. These assays can be used to predict if a patient will benefit from a particular treatment. This work includes: 1. enzymatic activity assays for dihydropyrimidine dehydrogenase, thymidine synthase, and polyADPribose polymerase. 2. assays for the enumeration of circulating epithelial and melanoma tumor cells.
Willeke Ros, MSc
My name is Willeke Ros and I am a PhD student at Jan Schellens group. I have completed my bachelor in Biology and my master in Biomedical Sciences at Leiden University. During my studies I have performed various internships focusing mostly on fundamental research questions. However, during my last internship at the University of Wisconsin-Madison, I did research which was part of clinical trials. I enjoyed the translational nature of the research and decided I wanted to continue doing clinical research. During my PhD studies I will focus on phase I/II clinical trials related to immunotherapy.
Vincent de Weger, MSc M.D.
In 2011 I finished medical school at the VU university. I also enrolled in the Honors program performing my own scientific project for which I was awarded the honors degree in Medicine. After medical school I have worked as a resident at Spaarne Hospital.
Currently I work as a PhD student. My work focuses on fase I and II drug development studies, both MODRA and sponsor initiated.
I'm a student from Utrecht University and at the moment I'm at
the second year of the master program ''Pharmacy''. I also achieved
my Bachelor degree at Utrecht University.
As a part of my master program I'm currently doing a 6-months internship at the NKI. The field of my internship is Pharmaco-economics and the projects aims to produce a detailed cost of illness model of metastatic Non-Small Cell Lung Carcinoma. My goal is to get more insight in pharmaco-economic research and hopefully contribute to the creation of a solid pharmaco-economical model.
Recent publications View All Publications
A phase I monotherapy study of RG7212, a first-in-class monoclonal antibody targeting TWEAK signaling in patients with advanced cancers
(2015) Clin Cancer Res. 2015 Jan 15;21(2):258-66. doi: 10.1158/1078-0432.CCR-14-1334. Epub 2014 Nov 11.
Lassen UN, Meulendijks D, Siu LL, Karanikas V, Mau-Sorensen M, Schellens JH, Jonker DJ, Hansen AR, Simcox ME, Schostack KJ, Bottino...
Integrated semi-physiological pharmacokinetic model for both sunitinib and its active metabolite SU12662
(2014) Br J Clin Pharmacol. 2014 Nov 12. doi: 10.1111/bcp.12550. [Epub ahead of print]
Yu H, Steeghs N, Kloth JS, de Wit D, van Hasselt JG, van Erp NP, Beijnen JH, Schellens JH, Mathijssen RH, Huitema AD.
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