Ga direct naar de inhoud, het hoofdmenu, het servicemenu of het zoekveld.

Molecular Pathology: Jan Schellens

JanSchellens.jpg

Jan Schellens, M.D. professorGroupleader

  • +31 20 512 2961
About Jan Schellens

Research interest: Personalized Cancer Treatment

Co-workers

Boot, Nienke.jpg

Nienke Boot, MSc

Research assistant

Experience

As research assistant I process the data from the clinical trials. 

 

 

 

 

 

Close this window
Brummelen, Emilie van.jpg

Emilie van Brummelen (MSc)

Ph.D. Student

Experience

I am doing my PhD in Prof. Jan Schellens' research group on the division of Molecular Pathology. In my research I focus on phase I/II clinical studies. I finished the Master in Pharmacy and the Honours Programme of Pharmaceutical Sciences at Utrecht University in the end of 2013. During my studies, I did an internship at Bayer Pharma in Berlin, and at several pharmacies and hospitals in the Netherlands. Next to that I worked on a research project on the development of polyomavirus-derived virus-like particles by directed evolution at the group of Pharmaceutics at Utrecht University. Also I did research on the effect of broccoli on the CYP2D6 phenotype in vitro and in vivo.
During my studies it became more and more clear that clinical research is one of my main interests. That brought me here to work on clinical trials for my PhD, to learn about all aspects of clinical research.

Close this window
silhouette_geen_foto_thumb_man.jpg

Artur Burylo

Technician

Personal details

Experience

Close this window
Geel, Robin.JPG

Robin van Geel, MSc

Ph.D. Student

Experience

As a PhD-student I work on early phase clinical studies focusing on targeted anti-cancer agents and combination strategies. One of my projects involves a phase I/II study combining a BRAF inhibitor with an EGFR inhibitor in patients with BRAF mutated metastatic colorectal cancer. This experimental therapy is based on preclinical data that suggested that both BRAF and EGFR should be targeted to effectively inhibit growth of BRAF mutated colorectal cancers. Preliminary results suggest that this treatment is very effective in this selected group of patients, with tumor responses in a substantial part of the patients at the expense of very limited adverse events.

 

Close this window
Jacobs, Bart.jpg

Bart Jacobs, MSc

Ph.D. Student

Experience

After finishing my Masters in Pharmacy in the end of 2011 (Utrecht University) I started working as a PhD student in the group of Prof. dr. J.H.M. Schellens. My research project is focused on the development and clinical testing of new oral fluoropyrimidine drugs in order to explore implications for chronotherapy. This research is supported by bioanalytical projects in order to develop and validate assays which can be applied in the clinical studies. In addition, to gain more insight in the pharmacology of oral fluoropyrimidines, I'm currently working on the development of a population based pharmacokinetic model for capecitabine.

 

Close this window
Milojkovic, Bojana

Bojana Milojkovic

Ph.D. Student

Experience

During my medical studies I was active in performing research on the department of Physiology and Sport Medicine. After finishing Medical school in Belgrade, Serbia and working at the Clinical hospital center "Dr Dragisa Misovic, Belgrade, I started working in an international company performing clinical trials.
Currently I work as a PhD student in the group of Prof Dr Jan Schellens focusing on phase I studies. In the cooperation with Dr Dieta Brandsma we are developing new strategies targeting brain tumors and clinically testing the assay for the enumeration of circulating epithelial and melanoma tumor cells in cerebrospinal fluid.

 

Close this window
silhouette_geen_foto_thumb_man.jpg

Ruud van der Noll

Ph.D. Student

Experience

I finished my Master in Pharmacy at the University of Utrecht in 2009. After working as a pharmacist for a little while, I decided to take on a more challenging position and started working as a PhD student for the Schellens group at the NKI.
My research mainly focuses on several phase I studies in which new compounds or new combinations of existing drugs are given to patients for the first time. In these studies we try to establish what the toxicities are and what the recommended dose is for future studies, but also investigate whether there is evidence of preliminary anti-tumor activity.

 

Close this window
silhouette_geen_foto_thumb_man.jpg

Dick Pluim, BSc

Technician

Experience

I am involved as an independent researcher in the development and validation of non-invasive predictive and pharmacodynamic biomarker assays for monitoring the effect of molecular targeted anticancer agents. These assays can be used to predict if a patient will benefit from a particular treatment. This work includes: 1. enzymatic activity assays for dihydropyrimidine dehydrogenase, thymidine synthase, and polyADPribose polymerase. 2. assays for the enumeration of circulating epithelial and melanoma tumor cells.

 

 

Close this window
Weger, Vincent de.jpg

Vincent de Weger, MSc M.D.

Ph.D. Student

Experience

In 2011 I finished medical school at the VU university. I also enrolled in the Honors program performing my own scientific project for which I was awarded the honors degree in Medicine. After medical school I have worked as a resident at Spaarne Hospital.

Currently I work as a PhD student. My work focuses on fase I and II drug development studies, both MODRA and sponsor initiated.

 

 

 

Close this window
 
 

Recent publications View All Publications

  • Erratum to: Effect of the drug transporters ABCG2, Abcg2, ABCB1 and ABCC2 on the disposition, brain accumulation and myelotoxicity of the aurora kinase B inhibitor barasertib and its more active form barasertib-hydroxy-QPA

    Invest New Drugs. 2013 [Epub ahead of print]

    Marchetti S, Pluim D, van Eijndhoven M, van Tellingen O, Mazzanti R, Beijnen JH, Schellens JH.

    Link to PubMed
  • Severe skin toxicity in pediatric oncology patients treated with voriconazole and concomitant methotrexate

    Antimicrob Agents Chemother. 2013 [Epub ahead of print]

    van Hasselt JG, van Eijkelenburg NK, Huitema AD, Schellens JH, Schouten-van Meeteren AY.

    Link to PubMed
 

Contact

  • Office manager

    Mirna Ekelschot - van Diermen

  • E-mail

    m.v.diermen@nki.nl

  • Telephone Number

    +31 20 512 9127

silhouette_geen_foto_thumb_vrouw.jpg

Donate

'Support for our research to test new treatments in patients based on breakthroughs in the lab'.

Support us