Within the NKI-AVL, many commercially relevant reagents are developed. These are made available to the research community and to commercial entities.
Antibodies
Examples of available antibodies are:
Murine 175F11 hybridoma cell line and antibody – Muc-1
Murine or Human 175F4 hybridoma cell line and antibody – Muc-1
Anti-pan MUC-1 (214D4)
Anti-MUC-1 non repeat section
Anti-Bmi-1 monoclonal
Anti-Tiam-1
Anti-NCAM
Anti-glucosidase
Anti-transferrin receptor hybridomas
Anti-lactoferrin hybridomas
Anti-Tbx-2 hybridomas
GoH3 clone – producing antibodies to CD49f
GAME-46 producing antibodies to CD18
Cell lines
Within the NKI-AVL, there are many cell lines available. These will be published in scientific papers, and will in general be available for commercial internal research. A selection of these lines is given below. All of the available PDFs for the cell lines can be obtained here.
Drug Transporter Cell lines
Examples of available cell lines are:
MDCK II cell line expressing BCRP1 (MDCKII-BCRP1)
HEK 293 cell line expressing MRP4
MDCK II cell line expressing MDR1 (MDCKII-MDR1)
MDCK II cell line expressing MRP1 (MDCKII-MRP1)
MDCK II cell line expressing MRP2 (MDCKII-MRP2)
MDCK II cell line expressing MRP3 (MDCKII-MRP3)
MDCK II cell line expressing MRP5 (MDCKII-MRP5)
2008 parental cell line expressing MRP1 (2008-MRP1)
2008 parental cell line expressing MRP2 (2008-MRP2)
2008 parental cell line expressing MRP3 (2008-MRP3)
HEK 293 cell line expressing MRP5 (HEK293 MRP5)
LLC-PK-1 cell line expressing MDR1
LLC-PK-1 cell line expressing Mdr1a
LLC-PK-1 cell line expressing Mdr1b
LLC-PK-1 cell line expressing MDR3
LLC-PK-1 cell line expressing MRP1
LLC-PK-1 cell line expressing MRP2
LLC-PK-1 cell line expressing MRP3
LLC-PK-1 cell line expressing Bcrp1
Cancer-related Cell lines
TrkB cell lines
Metastatic Breast Cancer (Ecd-/-,p53-/- KEP1.23)
Mouse models
The NKI-AVL has developed many mouse models, for example (conditionally) expressing strains, (conditional) knock-out strains and reporter strains). An example of these is the heterozygous autotaxin KO mouse (click here for more information about this model).
For a detailed list, please contact tto@nki.nl.