(36 hours a week)
Project information:
Sister chromatid cohesion mediated by the ring-shaped cohesin complex is essential for faithful chromosome segregation in mitosis and for high fidelity DNA damage repair through homologous recombination.
We offer a PhD student position on a project funded by the Dutch Cancer Society that consists of two parts. The first part will study the elusive mechanism by which sister chromatid cohesion is established in eukaryotic cells. This process takes place during S phase, but how cohesion establishment and DNA replication are coordinated is largely a mystery. The second part focuses on how and why cohesin is removed from chromosome arms in early mitosis of animal cells. This latter project in essence asks what causes human chromosomes to get their well-known X-shape. The project as a whole will be a mixture of genetics and imaging in mammalian cells, and also of genetics and biochemistry in budding yeast.
The project is supervised by Dr. Benjamin Rowland and Prof. Dr. René Medema, who will be moving to the NKI in October 2011. Ideally the project will start between October 2011 and January 2012.
Requirements:
We are looking for a motivated Postdoc with a passion for the cell cycle and chromosome biology. A background in molecular biology is required. Experience with microscopy, (yeast-) genetics and/or biochemistry will be appreciated. Please include your CV in your application Email to b.d.rowland@umcutrecht.nl.
Employment conditions:
The temporary employment will be for a period up to three years. The terms of employment will be in accordance with the Collective Labour Agreement for Hospitals and depends on previous experience. The gross monthly salary will be from € 3,153 to € 4,034 depending on previous experience. We can help you find housing in the area.
Want more information?
For more information about the project and the position, please contact Dr. Benjamin Rowland (b.d.rowland@umcutrecht.nl or +31 88 75 682 34), or check www.umcutrecht.nl/subsite/oncology/Research-groups/Rowland/.
Interested?
Your application letter and resume can be attached to the application form on our website (see link below). After dispatch of the form you will receive a reaction as soon as possible.
Only if the digital application fails, it is possible to send your application letter and resume to work@nki.nl, indicating the reference number in the subject line of the e-mail or in your letter.